Proline Dehydrogenase, Mitochondrial (PRODH)
PDH; PIG6; POX2; PRODH1; PRODH2; SCZD4; TP53I6; p53-induced gene 6 protein; L-Proline Dehydrogenase; L-Proline(acceptor)Oxidoreductase; Proline Oxidase 1
- Proline dehydrogenase, mitochondrial is a mitochondrial proline dehydrogenase which catalyzes the first step in proline catabolism. Deletion of this gene has been associated with type I hyperprolinemia. The gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes: DiGeorge syndrome and CATCH22 syndrome.
- This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors.This enzyme participates in arginine and proline metabolism. the two substrates of this enzyme are L-proline and acceptor, whereas its two products are (S)-1-pyrroline-5-carboxylate and reduced acceptor.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU102Hu01 | Recombinant Proline Dehydrogenase, Mitochondrial (PRODH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU102Hu01 | Monoclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IP. |
| PAU102Hu01 | Polyclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU102Hu01 | CLIA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | CLIA assay for Antigen Detection |
| ELU102Hu01 | ELISA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU102Mu01 | Recombinant Proline Dehydrogenase, Mitochondrial (PRODH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU102Mu01 | Monoclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IP. |
| PAU102Mu01 | Polyclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU102Mu01 | CLIA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | CLIA assay for Antigen Detection |
| ELU102Mu01 | ELISA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU102Ra01 | Recombinant Proline Dehydrogenase, Mitochondrial (PRODH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU102Ra01 | Monoclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IP. |
| PAU102Ra01 | Polyclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU102Ra01 | CLIA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | CLIA assay for Antigen Detection |
| ELU102Ra01 | ELISA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU102Ca01 | Recombinant Proline Dehydrogenase, Mitochondrial (PRODH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU102Ca01 | Monoclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IP. |
| PAU102Ca01 | Polyclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU102Ca01 | CLIA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | CLIA assay for Antigen Detection |
| ELU102Ca01 | ELISA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU102Po01 | Recombinant Proline Dehydrogenase, Mitochondrial (PRODH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU102Po01 | Monoclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IP. |
| PAU102Po01 | Polyclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU102Po01 | CLIA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | CLIA assay for Antigen Detection |
| ELU102Po01 | ELISA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU102Bo01 | Recombinant Proline Dehydrogenase, Mitochondrial (PRODH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU102Bo01 | Monoclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IP. |
| PAU102Bo01 | Polyclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU102Bo01 | CLIA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | CLIA assay for Antigen Detection |
| ELU102Bo01 | ELISA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU102Rb01 | Recombinant Proline Dehydrogenase, Mitochondrial (PRODH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU102Rb01 | Monoclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IP. |
| PAU102Rb01 | Polyclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU102Rb01 | CLIA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | CLIA assay for Antigen Detection |
| ELU102Rb01 | ELISA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPU102Mo01 | Recombinant Proline Dehydrogenase, Mitochondrial (PRODH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAU102Mo01 | Monoclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IP. |
| PAU102Mo01 | Polyclonal Antibody to Proline Dehydrogenase, Mitochondrial (PRODH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLU102Mo01 | CLIA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | CLIA assay for Antigen Detection |
| ELU102Mo01 | ELISA Kit for Proline Dehydrogenase, Mitochondrial (PRODH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"A human homologue of the Drosophila melanogaster sluggish-A (proline oxidase) gene maps to 22q11.2, and is a candidate gene for type-I hyperprolinaemia."
Hum. Genet. 101:69-74(1997) [PubMed] [Europe PMC] [Abstract]
"The gene encoding proline dehydrogenase modulates sensorimotor gating in mice."
Nat. Genet. 21:434-439(1999) [PubMed] [Europe PMC] [Abstract]
"Functional consequences of PRODH missense mutations."
Am. J. Hum. Genet. 76:409-420(2005) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A model for p53-induced apoptosis."
Nature 389:300-306(1997) [PubMed] [Europe PMC] [Abstract]
"PRODH mutations and hyperprolinemia in a subset of schizophrenic patients."
Hum. Mol. Genet. 11:2243-2249(2002) [PubMed] [Europe PMC] [Abstract]
"Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia."
Proc. Natl. Acad. Sci. U.S.A. 99:3717-3722(2002) [PubMed] [Europe PMC] [Abstract]
"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
"Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome."
Hum. Mol. Genet. 16:83-91(2007) [PubMed] [Europe PMC] [Abstract]