Poliovirus Receptor Related Protein 4 (PVRL4)

PRR4; LNIR; Nectin-4; Ig superfamily receptor LNIR; Processed poliovirus receptor-related protein 4

SPN	U100
HGNC	19688
MGI	1918990
PubMed	23682311
RGD	1559826
UniProt	Q96NY8

Poliovirus receptor-like proteins (PVRLs), such as PVRL4, are adhesion receptors of the immunoglobulin superfamily and function in cell-cell adhesion (Reymond et al., 2001).

By database analysis, Reymond et al. (2001) identified the PVRL4 gene, which encodes a 510-amino acid protein with a predicted molecular mass of 55.5 kD. It contains 1 predicted transmembrane domain, followed by a 139-residue cytoplasmic sequence. Human and murine PVRL4 share 92% amino acid identity. Northern blot analysis showed strong expression of a 3.7-kb human PVRL4 transcript in placenta and weak expression in trachea. Murine Pvrl4 was expressed at embryonic days 11, 15 and 17. Immunohistochemistry revealed human PVRL4 localized to endothelial cells from vessels in placental villi.

Reference

"Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction."
J. Biol. Chem. 276:43205-43215(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C'-D beta-strands of the nectin1 V domain."
J. Biol. Chem. 277:27006-27013(2002) [PubMed] [Europe PMC] [Abstract]

"Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17."
J. Biol. Chem. 280:19543-19550(2005) [PubMed] [Europe PMC] [Abstract]

"Nectin-4 is a new histological and serological tumor associated marker for breast cancer."
BMC Cancer 7:73-73(2007) [PubMed] [Europe PMC] [Abstract]

"Adherens junction protein nectin-4 is the epithelial receptor for measles virus."
Nature 480:530-533(2011) [PubMed] [Europe PMC] [Abstract]

"Nectin ectodomain structures reveal a canonical adhesive interface."
Nat. Struct. Mol. Biol. 19:906-915(2012) [PubMed] [Europe PMC] [Abstract]

"Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4."
Nat. Struct. Mol. Biol. 20:67-72(2013) [PubMed] [Europe PMC] [Abstract]

"Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome."
Am. J. Hum. Genet. 87:265-273(2010) [PubMed] [Europe PMC] [Abstract]