Regucalcin (RGN)

RC; SMP30; GNL; Senescence Marker Protein-30; Gluconolactonase

SPN	U092
HGNC	9989
MGI	108024
PubMed	15702226
RGD	3560
UniProt	Q15493
Wiki	Regucalcin

Regucalcinis a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.
Regucalcin is a proposed name for a calcium-binding protein that was discovered in 1978.Regucalcin differs from calmodulin and other Ca²⁺-related proteins as it does not contain an EF-hand motif of Ca²⁺-binding domain. It may regulate the effect of Ca²⁺ on liver cell functions.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U092Hu01	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	MU092Hu21	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	PU092Hu01	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U092Mu01	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	PU092Mu01	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	U092Ra01	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	PU092Ra01	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Regucalcin (RGN)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Regucalcin (RGN)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Regucalcin (RGN)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Regucalcin (RGN)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Regucalcin (RGN)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Regucalcin (RGN)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Regucalcin (RGN)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Regucalcin (RGN)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Regucalcin (RGN)	CLIA assay for Antigen Detection

Reference

"Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome."
Biochim. Biophys. Acta 1263:249-252(1995) [PubMed] [Europe PMC] [Abstract]

"Transcript heterogeneity of the human gene for Ca2+-binding protein regucalcin."
Int. J. Mol. Med. 5:283-287(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human senescence marker protein 30: insights linking structural, enzymatic, and physiological functions."
Biochemistry 49:3436-3444(2010) [PubMed] [Europe PMC] [Abstract]

"Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase."
PLoS ONE 8:E53706-E53706(2013) [PubMed] [Europe PMC] [Abstract]