Transgelin (TAGLN)

SMCC; SM22; TAGLN1; WS3-10; Transgelin Variant 2; 22 kDa actin-binding protein; Protein WS3-10; Smooth muscle protein 22-alpha

SPN	U076
HGNC	11553
MGI	106012
PubMed	8501116
RGD	3723
UniProt	Q01995
Wiki	TAGLN

Transgelin is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. In contrast to fast and slow skeletal muscle cells that fuse and terminally differentiate, smooth muscle cells are able to simultaneously proliferate and express lineage-restricted proteins. One of these proteins, expressed exclusively in smooth muscles, has been referred to as SM22-alpha, a 22-kD protein with structural similarity to the vertebrate thin filament myofibrillar regulatory protein calponin and the Drosophila muscle protein mp20, neither of which play a direct role in the contractile apparatus.

Reference

"A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts."
Biochem. Biophys. Res. Commun. 187:1-7(1992) [PubMed] [Europe PMC] [Abstract]

"Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle."
Biochem. Int. 23:663-668(1991) [PubMed] [Europe PMC] [Abstract]

"Expression and cytogenetic localization of the human SM22 gene (TAGLN)."
Genomics 49:452-457(1998) [PubMed] [Europe PMC] [Abstract]

"Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation."
J. Biochem. 122:157-167(1997) [PubMed] [Europe PMC] [Abstract]

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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]