Tenomodulin (TNMD)
TEM; BRICD4; CHM1-LIKE; CHM1L; Myodulin; Tendin; Chondromodulin-1-like protein
By searching an EST database for sequences similar to mouse Tem, followed by RACE of a human fetus cDNA library, Shukunami et al. (2001) cloned TEM. The deduced 317-amino acid protein contains an N-terminal transmembrane domain and a putative antiangiogenic domain with 8 cysteines.
TEM shares 96% amino acid identity with mouse Tem, and it shares 65% identity in a 65-amino acid C-terminal stretch with chondromodulin I (CHM1). Northern blot analysis of several mouse tissues detected a 1.4-kb transcript expressed specifically in skeletal muscle. In situ hybridization revealed mouse Tem expression in dense connective tissue, such as epimysium and tendon.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U059Hu01 | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | MU059Hu22 | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| PU059Hu01 | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | KEU059Hu | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tenomodulin (TNMD) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tenomodulin (TNMD) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tenomodulin (TNMD) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tenomodulin (TNMD) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tenomodulin (TNMD) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tenomodulin (TNMD) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tenomodulin (TNMD) | CLIA assay for Antigen Detection |
Reference
"Molecular cloning and characterization of ChM1L, a novel membrane molecule similar to chondromodulin-I."
Biochem. Biophys. Res. Commun. 280:1101-1106(2001) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of tenomodulin, a novel chondromodulin-I related gene."
Biochem. Biophys. Res. Commun. 280:1323-1327(2001) [PubMed] [Europe PMC] [Abstract]
"A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I."
Dev. Dyn. 221:72-80(2001) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
"Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss."
J. Clin. Endocrinol. Metab. 94:3987-3994(2009) [PubMed] [Europe PMC] [Abstract]
"Tendon-selective genes identified from rat and human musculoskeletal tissues."
J. Orthop. Res. 28:289-297(2010) [PubMed] [Europe PMC] [Abstract]
"Differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin."
J. Appl. Physiol. 113:861-871(2012) [PubMed] [Europe PMC] [Abstract]