Toll Interacting Protein (TOLLIP)

IL-1RAcPIP

SPN	U054
HGNC	16476
MGI	1891808
PubMed	10854325
RGD	1304676
UniProt	Q9H0E2
Wiki	TOLLIP

Toll interacting protein, also known as TOLLIP, is an inhibitory adaptor protein .It is an inhibitory adaptor protein within Toll-like receptors (TLR). The TLR pathway is a part of the innate immune system that recognizes structurally conserved molecular patterns of microbial pathogens, leading to an inflammatory immune response.

Compared with the full-length isoform, 2 of the human proteins lack the N-terminal TBD, and 1 lacks the C2 domain. A mouse-specific isoform lacks the C-terminal CUE domain. EST database analysis suggested that full-length human TOLLIP is ubiquitously expressed. Expression of the other human variants appeared to be more restricted, with evidence for enrichment in brain.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	MU054Hu21	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	PU054Hu01	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	KEU054Hu	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	PU054Mu01	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Toll Interacting Protein (TOLLIP)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Toll Interacting Protein (TOLLIP)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Toll Interacting Protein (TOLLIP)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Toll Interacting Protein (TOLLIP)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Toll Interacting Protein (TOLLIP)	CLIA assay for Antigen Detection

Reference

"Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor."
Nat. Cell Biol. 2:346-351(2000) [PubMed] [Europe PMC] [Abstract]

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Negative regulation of Toll-like receptor-mediated signaling by Tollip."
J. Biol. Chem. 277:7059-7065(2002) [PubMed] [Europe PMC] [Abstract]

"Recruitment of clathrin onto endosomes by the Tom1-Tollip complex."
Biochem. Biophys. Res. Commun. 341:143-149(2006) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"Autophagic clearance of PolyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family."
Cell 158:549-563(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of CUE domain in the C-terminal of human Toll-interacting protein (TOLLIP)."
Submitted (NOV-2004) to the PDB data bank