Thromboxane Receptor (TP)

TBXA2R; TXA2-R; Thromboxane A2 Receptor; Prostanoid TP receptor

SPN	U035
HGNC	11608
MGI	98496
PubMed	14751539
RGD	3825
UniProt	P21731
Wiki	TP

The TP) is a protein on the surface of cells in the endothelium of blood vessels and in the placenta which interacts with the eicosanoid lipid thromboxane. It is a G-protein coupled receptors coupled to the G protein G_q.The gene responsible for the thromboxane receptor, TBXA2R is found on chromosome 19 and spans 15 kilobases.

Thromboxane is a potent stimulator for platelet aggregation and clot formation and also plays a role in vascular tone. The thromboxane receptor is a member of the family of G protein-coupled receptors. Mutation of the receptor can lead to a bleeding disorder.

Reference

"Cloning and expression of cDNA for a human thromboxane A2 receptor."
Nature 349:617-620(1991) [PubMed] [Europe PMC] [Abstract]

"Characterization and chromosomal mapping of the human thromboxane A2 receptor gene."
J. Biol. Chem. 268:25253-25259(1993) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor."
J. Biol. Chem. 269:19256-19261(1994) [PubMed] [Europe PMC] [Abstract]

Erratum
J. Biol. Chem. 270:7011-7011(1995) [PubMed] [Europe PMC] [Abstract]

"Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells."
J. Pharmacol. Exp. Ther. 271:1034-1041(1994) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation."
J. Clin. Invest. 97:949-956(1996) [PubMed] [Europe PMC] [Abstract]

"Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites."
Mol. Pharmacol. 44:934-939(1993) [PubMed] [Europe PMC] [Abstract]

"Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes."
Prostaglandins Other Lipid Mediat. 83:237-249(2007) [PubMed] [Europe PMC] [Abstract]

"RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2)."
Traffic 9:394-407(2008) [PubMed] [Europe PMC] [Abstract]

"Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor."
Prostaglandins Other Lipid Mediat. 89:8-15(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder."
J. Clin. Invest. 94:1662-1667(1994) [PubMed] [Europe PMC] [Abstract]