Neurotensin Receptor 1, High Affinity (NTSR1)

NTR; NTRH; NTRR; High-affinity levocabastine-insensitive neurotensin receptor

SPN	U031
HGNC	8039
MGI	97386
PubMed	11032391
RGD	1306076
UniProt	P30989
Wiki	NTSR1

Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.

The neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin. Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. The third receptor has a single transmembrane domain and is encoded by the SORT1 gene.

Reference

"Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor."
FEBS Lett. 317:139-142(1993) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer."
Cancer Res. 70:347-356(2010) [PubMed] [Europe PMC] [Abstract]

"Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains."
Cancer Biol. Ther. 12:427-435(2011) [PubMed] [Europe PMC] [Abstract]

"Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor."
J. Biomol. Struct. Dyn. 31:1381-1392(2013) [PubMed] [Europe PMC] [Abstract]