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Syntenin 1 (ST1)

SDCBP; MDA9; SYCL; TACIP18; Syndecan Binding Protein; Scaffold protein Pbp1; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting 18

Syntenin-1 is a protein initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors.
The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU020Hu01 Recombinant Syntenin 1 (ST1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU020Hu01 Monoclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IP.
PAU020Hu01 Polyclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IF.
Assay Kits CLU020Hu01 CLIA Kit for Syntenin 1 (ST1) CLIA assay for Antigen Detection
ELU020Hu01 ELISA Kit for Syntenin 1 (ST1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU020Mu01 Recombinant Syntenin 1 (ST1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU020Mu01 Monoclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IP.
PAU020Mu01 Polyclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IF.
Assay Kits CLU020Mu01 CLIA Kit for Syntenin 1 (ST1) CLIA assay for Antigen Detection
ELU020Mu01 ELISA Kit for Syntenin 1 (ST1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU020Ra01 Recombinant Syntenin 1 (ST1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU020Ra01 Monoclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IP.
PAU020Ra01 Polyclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IF.
Assay Kits CLU020Ra01 CLIA Kit for Syntenin 1 (ST1) CLIA assay for Antigen Detection
ELU020Ra01 ELISA Kit for Syntenin 1 (ST1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU020Ca01 Recombinant Syntenin 1 (ST1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU020Ca01 Monoclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IP.
PAU020Ca01 Polyclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IF.
Assay Kits CLU020Ca01 CLIA Kit for Syntenin 1 (ST1) CLIA assay for Antigen Detection
ELU020Ca01 ELISA Kit for Syntenin 1 (ST1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU020Po01 Recombinant Syntenin 1 (ST1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU020Po01 Monoclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IP.
PAU020Po01 Polyclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IF.
Assay Kits CLU020Po01 CLIA Kit for Syntenin 1 (ST1) CLIA assay for Antigen Detection
ELU020Po01 ELISA Kit for Syntenin 1 (ST1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU020Bo01 Recombinant Syntenin 1 (ST1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU020Bo01 Monoclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IP.
PAU020Bo01 Polyclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IF.
Assay Kits CLU020Bo01 CLIA Kit for Syntenin 1 (ST1) CLIA assay for Antigen Detection
ELU020Bo01 ELISA Kit for Syntenin 1 (ST1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU020Rb01 Recombinant Syntenin 1 (ST1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU020Rb01 Monoclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IP.
PAU020Rb01 Polyclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IF.
Assay Kits CLU020Rb01 CLIA Kit for Syntenin 1 (ST1) CLIA assay for Antigen Detection
ELU020Rb01 ELISA Kit for Syntenin 1 (ST1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPU020Mo01 Recombinant Syntenin 1 (ST1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAU020Mo01 Monoclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IP.
PAU020Mo01 Polyclonal Antibody to Syntenin 1 (ST1) WB; IHC; ICC; IF.
Assay Kits CLU020Mo01 CLIA Kit for Syntenin 1 (ST1) CLIA assay for Antigen Detection
ELU020Mo01 ELISA Kit for Syntenin 1 (ST1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"Syntenin, a PDZ protein that binds syndecan cytoplasmic domains."
Proc. Natl. Acad. Sci. U.S.A. 94:13683-13688(1997) [PubMed] [Europe PMC] [Abstract]

"Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene."
Gene 207:105-110(1998) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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, Submitted (FEB-2009) to UniProtKB

"PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands."
Neuron 21:1453-1463(1998) [PubMed] [Europe PMC] [Abstract]

"A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface."
Mol. Cell 3:423-433(1999) [PubMed] [Europe PMC] [Abstract]

"Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin."
J. Biol. Chem. 275:19933-19941(2000) [PubMed] [Europe PMC] [Abstract]

"Schwannomin isoform-1 interacts with syntenin via PDZ domains."
J. Biol. Chem. 276:33093-33100(2001) [PubMed] [Europe PMC] [Abstract]

"Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments."
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"Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein."
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"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"PDZ tandem of human syntenin: crystal structure and functional properties."
Structure 11:459-468(2003) [PubMed] [Europe PMC] [Abstract]

"Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm."
Structure 11:845-853(2003) [PubMed] [Europe PMC] [Abstract]

"The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography."
J. Mol. Biol. 338:483-493(2004) [PubMed] [Europe PMC] [Abstract]

"The binding of the PDZ tandem of syntenin to target proteins."
Biochemistry 45:3674-3683(2006) [PubMed] [Europe PMC] [Abstract]