S-Phase Kinase Associated Protein 2 (SKP2)

FBL1; FBXL1; FLB1; p45; Cyclin-A/CDK2-associated protein p45; F-box/LRR-repeat protein 1; p45skp2

SPN	U010
HGNC	10901
MGI	1351663
PubMed	12769843
RGD	1562456
UniProt	Q13309
Wiki	SKP2

S-phase kinase-associated protein 2 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase.

Reference

"p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase."
Cell 82:915-925(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2)."
Genes Dev. 16:2946-2957(2002) [PubMed] [Europe PMC] [Abstract]

"Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication."
Mol. Cell 9:481-491(2002) [PubMed] [Europe PMC] [Abstract]

"The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation."
J. Biol. Chem. 278:30854-30858(2003) [PubMed] [Europe PMC] [Abstract]

"The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription."
Mol. Cell 11:1189-1200(2003) [PubMed] [Europe PMC] [Abstract]

"The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase."
J. Biol. Chem. 279:46424-46430(2004) [PubMed] [Europe PMC] [Abstract]

"Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection."
Biochemistry 44:14553-14564(2005) [PubMed] [Europe PMC] [Abstract]

"Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle."
Mol. Cell 18:699-709(2005) [PubMed] [Europe PMC] [Abstract]

"Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation."
J. Virol. 79:11135-11141(2005) [PubMed] [Europe PMC] [Abstract]

"Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation."
Proc. Natl. Acad. Sci. U.S.A. 102:1649-1654(2005) [PubMed] [Europe PMC] [Abstract]

"Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination."
Cancer Res. 66:8477-8483(2006) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2."
Mol. Cell. Biol. 26:3114-3123(2006) [PubMed] [Europe PMC] [Abstract]

"Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein."
Mol. Cell. Biol. 26:5994-6004(2006) [PubMed] [Europe PMC] [Abstract]

"Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions."
Genes Dev. 21:2385-2398(2007) [PubMed] [Europe PMC] [Abstract]

"Ubiquitination and degradation of Tal1/SCL are induced by Notch signaling and depend on Skp2 and CHIP."
J. Biol. Chem. 283:684-692(2008) [PubMed] [Europe PMC] [Abstract]

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control."
Proc. Natl. Acad. Sci. U.S.A. 108:9119-9124(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Acetylation-dependent regulation of Skp2 function."
Cell 150:179-193(2012) [PubMed] [Europe PMC] [Abstract]

"Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex."
Nature 408:381-386(2000) [PubMed] [Europe PMC] [Abstract]

"Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex."
Nature 416:703-709(2002) [PubMed] [Europe PMC] [Abstract]