Spermine Synthase (SMS)
SPMSY; Spermidine aminopropyltransferase
Spermine synthase (EC 2.5.1.22) is 1 of 4 enzymes involved in the synthesis of polyamines from arginine and methionine. The others are ornithine decarboxylase, S-adenosyl-L-methionine decarboxylase , and spermidine synthase.Korhonen et al. (1995) isolated and sequenced cDNA clones encoding human spermine synthase.
The open reading frame encodes a 368-amino acid protein with little sequence similarity to proteins from bacterial and mammalian sources catalyzing almost identical reactions.In affected members of a family with Snyder-Robinson mental retardation syndrome (SRS) originally reported by Snyder and Robinson (1969), Cason et al. (2003) identified a splice site mutation in the SMS gene .
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | U004Hu01 | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| PU004Hu01 | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Spermine Synthase (SMS) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Spermine Synthase (SMS) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Spermine Synthase (SMS) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Spermine Synthase (SMS) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Spermine Synthase (SMS) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Spermine Synthase (SMS) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Spermine Synthase (SMS) | CLIA assay for Antigen Detection |
Reference
"Molecular cloning of a cDNA encoding human spermine synthase."
DNA Cell Biol. 14:841-847(1995) [PubMed] [Europe PMC] [Abstract]
"Sequence analysis of 139 kb in Xp22.1 containing spermine synthase and the 5' region of PEX."
Genomics 44:227-231(1997) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
(In) Goldemberg S.H., Algranati I.D. (eds.);Proceedings of the international symposium on the biology and chemistry of polyamines, pp.91-98, ICSU Press, New York (1988)
"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
"X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome."
Eur. J. Hum. Genet. 11:937-944(2003) [PubMed] [Europe PMC] [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism."
J. Biol. Chem. 283:16135-16146(2008) [PubMed] [Europe PMC] [Abstract]
"Targeted next generation sequencing as a diagnostic tool in epileptic disorders."
Epilepsia 53:1387-1398(2012) [PubMed] [Europe PMC] [Abstract]
"De novo loss-of-function mutations in SETD5, encoding a methyltransferase in a 3p25 microdeletion syndrome critical region, cause intellectual disability."
Am. J. Hum. Genet. 94:618-624(2014) [PubMed] [Europe PMC] [Abstract]