Serglycin (SRGN)

PRG; PPG; PRG1; proteoglycan 1, secretory granule

SPN	T988
HGNC	9361
MGI	97756
PubMed	22252637
RGD	619969
UniProt	P10124
Wiki	SRGN

Serglycin is a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis.Serglycin plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2.

Reference

"Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells."
J. Biol. Chem. 263:7287-7291(1988) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein."
Nucleic Acids Res. 17:7523-7523(1989) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product."
J. Biol. Chem. 265:5889-5896(1990) [PubMed] [Europe PMC] [Abstract]

"The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells."
J. Biol. Chem. 267:13558-13563(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Complete amino acid sequence of a human platelet proteoglycan."
FEBS Lett. 236:123-126(1988) [PubMed] [Europe PMC] [Abstract]

"Characterization and N-terminal sequence of human platelet proteoglycan."
Biochem. J. 255:1007-1013(1988) [PubMed] [Europe PMC] [Abstract]

"Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells."
Blood 97:449-458(2001) [PubMed] [Europe PMC] [Abstract]

"Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation."
Immunity 16:417-428(2002) [PubMed] [Europe PMC] [Abstract]

"Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin."
J. Biol. Chem. 277:49523-49530(2002) [PubMed] [Europe PMC] [Abstract]

"Localization of serglycin in human neutrophil granulocytes and their precursors."
J. Leukoc. Biol. 76:406-415(2004) [PubMed] [Europe PMC] [Abstract]

"Secretion of proteases in serglycin transfected Madin-Darby canine kidney cells."
FEBS J. 273:536-547(2006) [PubMed] [Europe PMC] [Abstract]

"Serglycin constitutively secreted by myeloma plasma cells is a potent inhibitor of bone mineralization in vitro."
J. Biol. Chem. 281:35116-35128(2006) [PubMed] [Europe PMC] [Abstract]