Supervillin (SVIL)
p205/p250; Archvillin
Supervillin is a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. Its function may include recruitment of actin and other cytoskeletal proteins into specialized structures at the plasma membrane and in the nuclei of growing cells. Two transcript variants encoding different isoforms of supervillin have been described.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | T976Hu01 | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | MT976Hu21 | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| PT976Hu01 | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| LT976Hu71 | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Supervillin (SVIL) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Supervillin (SVIL) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Supervillin (SVIL) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Supervillin (SVIL) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Supervillin (SVIL) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Supervillin (SVIL) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Supervillin (SVIL) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Supervillin (SVIL) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Supervillin (SVIL) | CLIA assay for Antigen Detection |
Reference
"Cloning, characterization, and chromosomal localization of human supervillin (SVIL)."
Genomics 52:342-351(1998) [PubMed] [Europe PMC] [Abstract]
"Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton."
J. Cell Sci. 116:2261-2275(2003) [PubMed] [Europe PMC] [Abstract]
"Supervillin-mediated suppression of p53 protein enhances cell survival."
J. Biol. Chem. 288:7918-7929(2013) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
"Archvillin anchors in the Z-line of skeletal muscle via the nebulin C-terminus."
Biochem. Biophys. Res. Commun. 374:320-324(2008) [PubMed] [Europe PMC] [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
"Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency."
Mol. Biol. Cell 20:948-962(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"How to arm a supervillin: designing F-actin binding activity into supervillin headpiece."
J. Mol. Biol. 393:608-618(2009) [PubMed] [Europe PMC] [Abstract]