Synaptotagmin I (SYT1)

SYT; P65; SVP65; Synaptotagmin 1

SPN	T971
HGNC	11509
MGI	99667
PubMed	12900172
RGD	3803
UniProt	P21579
Wiki	Synaptotagmin

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2 ) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse.

synaptotagmin, a highly conserved synaptic vesicle protein, binds calcium at physiologic concentrations in a complex with negatively charged phospholipids. This binding is specific for calcium and involves the cytoplasmic domain of synaptotagmin. Calcium binding is dependent on the intact oligomeric structure of synaptotagmin; it is abolished by proteolytic cleavage at a single site.

Reference

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"Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling."
J. Clin. Invest. 125:1670-1678(2015) [PubMed] [Europe PMC] [Abstract]