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Deoxyhypusine Synthase (DHPS)

MIG13; DHS; DS; Migration-Inducing Gene 13

The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A.
In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins T957Hu01 Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
PT957Hu01 Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins T957Mu01 Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
PT957Mu01 Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Deoxyhypusine Synthase (DHPS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Deoxyhypusine Synthase (DHPS) Bioactivity
Antibodies NONE Monoclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Deoxyhypusine Synthase (DHPS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Deoxyhypusine Synthase (DHPS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Deoxyhypusine Synthase (DHPS) CLIA assay for Antigen Detection

Reference

"Cloning and expression of human deoxyhypusine synthase cDNA. Structure-function studies with the recombinant enzyme and mutant proteins."
J. Biol. Chem. 270:22386-22392(1995) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus."
FEBS Lett. 378:195-198(1996) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information."
Biochem. J. 315:429-434(1996) [PubMed] [Europe PMC] [Abstract]

"Localization and genomic structure of human deoxyhypusine synthase gene on chromosome 19p13.2-distal 19p13.1."
Gene 215:153-157(1998) [PubMed] [Europe PMC] [Abstract]

"Large-scale concatenation cDNA sequencing."
Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of human deoxyhypusine synthase from HeLa cells."
FEBS Lett. 364:207-210(1995) [PubMed] [Europe PMC] [Abstract]

"Enzyme-substrate intermediate at a specific lysine residue is required for deoxyhypusine synthesis. The role of Lys329 in human deoxyhypusine synthase."
J. Biol. Chem. 272:32679-32685(1997) [PubMed] [Europe PMC] [Abstract]

"Structure-function studies of human deoxyhypusine synthase: identification of amino acid residues critical for the binding of spermidine and NAD."
Biochem. J. 355:841-849(2001) [PubMed] [Europe PMC] [Abstract]

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site."
Structure 6:23-32(1998) [PubMed] [Europe PMC] [Abstract]

"A new crystal structure of deoxyhypusine synthase reveals the configuration of the active enzyme and of an enzyme.NAD.inhibitor ternary complex."
J. Biol. Chem. 279:28697-28705(2004) [PubMed] [Europe PMC] [Abstract]