Pim-1 Oncogene (PIM1)

Proto-Oncogene Serine/Threonine-Protein Kinase Pim-1

SPN	T939
HGNC	8986
MGI	97584
PubMed	1825810
RGD	3330
UniProt	P11309
Wiki	PIM1

Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme encoded by the PIM1 gene. The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer (Dhanasekaran et al., 2001).Viral leukemogenesis in mice is often initiated by proviral activation of the highly conserved cellular gene Pim1. Domen et al. (1987) compared the nucleotide sequence of human and mouse PIM1 cDNAs. Meeker et al. (1987) also characterized the human PIM1 gene. The deduced amino acid sequence showed significant homology to a number of the protein kinases but did not have a transmembrane region. Studies of expression of this gene using Northern blots of human cell lines showed it to be transcribed primarily in B-lymphoid and myeloid cell lines.

Reference

"Primary structure of the putative human oncogene, pim-1."
Gene 90:303-307(1990) [PubMed] [Europe PMC] [Abstract]

"The cDNA sequence and gene analysis of the human pim oncogene."
Gene 54:105-111(1987) [PubMed] [Europe PMC] [Abstract]

"Comparison of the human and mouse PIM-1 cDNAs: nucleotide sequence and immunological identification of the in vitro synthesized PIM-1 protein."
Oncogene Res. 1:103-112(1987) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of the human PIM-1 gene: a putative oncogene related to the protein kinases."
J. Cell. Biochem. 35:105-112(1987) [PubMed] [Europe PMC] [Abstract]

"The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs."
Oncogene 25:70-78(2006) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas."
Nature 412:341-346(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity."
Mol. Cell. Biol. 8:1498-1503(1988) [PubMed] [Europe PMC] [Abstract]

"The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG."
EMBO J. 10:655-664(1991) [PubMed] [Europe PMC] [Abstract]

"Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1."
FEBS Lett. 467:17-21(2000) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase."
Biochim. Biophys. Acta 1593:45-55(2002) [PubMed] [Europe PMC] [Abstract]

"Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects."
Anticancer Res. 23:167-178(2003) [PubMed] [Europe PMC] [Abstract]

"Protein phosphatase 2A regulates the stability of Pim protein kinases."
J. Biol. Chem. 278:4800-4805(2003) [PubMed] [Europe PMC] [Abstract]

"IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils."
J. Immunol. 173:6409-6417(2004) [PubMed] [Europe PMC] [Abstract]

"Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway."
Mol. Cancer Res. 3:170-181(2005) [PubMed] [Europe PMC] [Abstract]

"The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C."
Int. J. Biochem. Cell Biol. 38:430-443(2006) [PubMed] [Europe PMC] [Abstract]

"Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels."
Cancer Res. 68:5076-5085(2008) [PubMed] [Europe PMC] [Abstract]

"PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis."
Oncogene 28:4261-4271(2009) [PubMed] [Europe PMC] [Abstract]

"Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002."
J. Biol. Chem. 280:13728-13734(2005) [PubMed] [Europe PMC] [Abstract]

"Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase."
J. Biol. Chem. 280:6130-6137(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma."
J. Mol. Biol. 348:183-193(2005) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]