Fibroblast Growth Factor 5 (FGF5)

HBGF5; Smag82; Heparin-binding growth factor 5

SPN	T926
HGNC	3683
MGI	95519
PubMed	11066093
RGD	620129
UniProt	P12034
Wiki	FGF5

Fibroblast growth factor 5 isa member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.

This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Reference

"Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system."
Proc. Natl. Acad. Sci. U.S.A. 87:8022-8026(1990) [PubMed] [Europe PMC] [Abstract]

"The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors."
Mol. Cell. Biol. 8:3487-3495(1988) [PubMed] [Europe PMC] [Abstract]

"Differential display identification of 40 genes with altered expression in activated human smooth muscle cells. Local expression in atherosclerotic lesions of smags, smooth muscle activation-specific genes."
J. Biol. Chem. 275:23939-23947(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas."
Cancer Res. 61:5511-5516(2001) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Receptor specificity of the fibroblast growth factor family."
J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]

"Fibroblast growth factor signalling: from development to cancer."
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]

"FGF5 is a crucial regulator of hair length in humans."
Proc. Natl. Acad. Sci. U.S.A. 111:10648-10653(2014) [PubMed] [Europe PMC] [Abstract]