Fibroblast Growth Factor 3 (FGF3)

HBGF3; INT2; Heparin-binding growth factor 3; Murine Mammary Tumor Virus Integration Site(v-int-2)Oncogene Homolog; INT-2 Proto-Oncogene Protein; Proto-oncogene Int-2

SPN	T921
HGNC	3681
MGI	95517
PubMed	11959820
RGD	620126
UniProt	P11487
Wiki	FGF3

FGF3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.

The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.

Reference

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"Fibroblast growth factor signalling: from development to cancer."
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]

"Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia."
Am. J. Hum. Genet. 80:338-344(2007) [PubMed] [Europe PMC] [Abstract]

"Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia."
Clin. Genet. 73:554-565(2008) [PubMed] [Europe PMC] [Abstract]