Fibroblast Growth Factor 22 (FGF22)

SPN	T918
HGNC	3679
MGI	1914362
PubMed	15260994
RGD	620177
UniProt	Q9HCT0
Wiki	FGF22

Fibroblast growth factor 22 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth,morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development.FGF22 encodes a deduced 170-amino acid protein with a hydrophobic amino terminus presumed to be a signal sequence. The protein shares 46% and 40% sequence identity with FGF10 and FGF7, respectively. It shares 87% sequence identity with mouse Fgf22.

Reference

"Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle."
Biochim. Biophys. Acta 1517:460-463(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair."
Oncogene 24:5269-5277(2005) [PubMed] [Europe PMC] [Abstract]

"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]

"Fibroblast growth factor signalling: from development to cancer."
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]