Fibroblast Growth Factor 20 (FGF20)

SPN	T915
HGNC	3677
MGI	1891346
PubMed	16373575
RGD	71068
UniProt	Q9NP95
Wiki	FGF20

Fibroblast growth factor 20is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT915Hu01	Recombinant Fibroblast Growth Factor 20 (FGF20)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT915Hu01	Monoclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IP.
Antibodies	PAT915Hu01	Polyclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IF.
Assay Kits	CLT915Hu01	CLIA Kit for Fibroblast Growth Factor 20 (FGF20)	CLIA assay for Antigen Detection
Assay Kits	ELT915Hu01	ELISA Kit for Fibroblast Growth Factor 20 (FGF20)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT915Mu01	Recombinant Fibroblast Growth Factor 20 (FGF20)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT915Mu01	Monoclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IP.
Antibodies	PAT915Mu01	Polyclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IF.
Assay Kits	CLT915Mu01	CLIA Kit for Fibroblast Growth Factor 20 (FGF20)	CLIA assay for Antigen Detection
Assay Kits	ELT915Mu01	ELISA Kit for Fibroblast Growth Factor 20 (FGF20)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT915Ra01	Recombinant Fibroblast Growth Factor 20 (FGF20)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT915Ra01	Monoclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IP.
Antibodies	PAT915Ra01	Polyclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IF.
Assay Kits	CLT915Ra01	CLIA Kit for Fibroblast Growth Factor 20 (FGF20)	CLIA assay for Antigen Detection
Assay Kits	ELT915Ra01	ELISA Kit for Fibroblast Growth Factor 20 (FGF20)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT915Ca01	Recombinant Fibroblast Growth Factor 20 (FGF20)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT915Ca01	Monoclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IP.
Antibodies	PAT915Ca01	Polyclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IF.
Assay Kits	CLT915Ca01	CLIA Kit for Fibroblast Growth Factor 20 (FGF20)	CLIA assay for Antigen Detection
Assay Kits	ELT915Ca01	ELISA Kit for Fibroblast Growth Factor 20 (FGF20)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT915Po01	Recombinant Fibroblast Growth Factor 20 (FGF20)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT915Po01	Monoclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IP.
Antibodies	PAT915Po01	Polyclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IF.
Assay Kits	CLT915Po01	CLIA Kit for Fibroblast Growth Factor 20 (FGF20)	CLIA assay for Antigen Detection
Assay Kits	ELT915Po01	ELISA Kit for Fibroblast Growth Factor 20 (FGF20)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT915Bo01	Recombinant Fibroblast Growth Factor 20 (FGF20)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT915Bo01	Monoclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IP.
Antibodies	PAT915Bo01	Polyclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IF.
Assay Kits	CLT915Bo01	CLIA Kit for Fibroblast Growth Factor 20 (FGF20)	CLIA assay for Antigen Detection
Assay Kits	ELT915Bo01	ELISA Kit for Fibroblast Growth Factor 20 (FGF20)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT915Rb01	Recombinant Fibroblast Growth Factor 20 (FGF20)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT915Rb01	Monoclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IP.
Antibodies	PAT915Rb01	Polyclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IF.
Assay Kits	CLT915Rb01	CLIA Kit for Fibroblast Growth Factor 20 (FGF20)	CLIA assay for Antigen Detection
Assay Kits	ELT915Rb01	ELISA Kit for Fibroblast Growth Factor 20 (FGF20)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPT915Mo01	Recombinant Fibroblast Growth Factor 20 (FGF20)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAT915Mo01	Monoclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IP.
Antibodies	PAT915Mo01	Polyclonal Antibody to Fibroblast Growth Factor 20 (FGF20)	WB; IHC; ICC; IF.
Assay Kits	CLT915Mo01	CLIA Kit for Fibroblast Growth Factor 20 (FGF20)	CLIA assay for Antigen Detection
Assay Kits	ELT915Mo01	ELISA Kit for Fibroblast Growth Factor 20 (FGF20)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22."
Biochem. Biophys. Res. Commun. 274:337-343(2000) [PubMed] [Europe PMC] [Abstract]

"FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain."
Biochem. Biophys. Res. Commun. 277:355-360(2000) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis."
Cancer Res. 61:3131-3138(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
J. Biol. Chem. 281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]

"Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein."
Am. J. Hum. Genet. 82:283-289(2008) [PubMed] [Europe PMC] [Abstract]

"FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression."
Mov. Disord. 24:455-459(2009) [PubMed] [Europe PMC] [Abstract]

"Fibroblast growth factor signalling: from development to cancer."
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]

"FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man."
Dev. Cell 22:1191-1207(2012) [PubMed] [Europe PMC] [Abstract]

"Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix."
Mol. Cell. Biol. 29:4663-4678(2009) [PubMed] [Europe PMC] [Abstract]