Platelet Derived Growth Factor C (PDGFC)

PDGF-C; SCDGF; VEGF-E; Fallotein; Spinal cord-derived growth factor; Platelet-derived growth factor C, latent form; Platelet-derived growth factor C, receptor-binding form

SPN	T907
HGNC	8801
MGI	1859631
PubMed	10806482
RGD	68410
UniProt	Q9NRA1
Wiki	PDGFC

Platelet-derived growth factor C is a member of the platelet-derived growth factor family. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain.Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation.

Reference

"Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract."
Biochim. Biophys. Acta 1492:196-202(2000) [PubMed] [Europe PMC] [Abstract]

"A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family."
FEBS Lett. 475:97-102(2000) [PubMed] [Europe PMC] [Abstract]

"PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor."
Nat. Cell Biol. 2:302-309(2000) [PubMed] [Europe PMC] [Abstract]

"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."
J. Biol. Chem. 276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes."
Circulation 103:2242-2247(2001) [PubMed] [Europe PMC] [Abstract]

"PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors."
Oncogene 20:626-633(2001) [PubMed] [Europe PMC] [Abstract]

"Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells."
Biochem. Biophys. Res. Commun. 296:604-611(2002) [PubMed] [Europe PMC] [Abstract]

"Characterization of platelet-derived growth factor-C (PDGF-C): expression in normal and tumor cells, biological activity and chromosomal localization."
Int. J. Biochem. Cell Biol. 34:414-426(2002) [PubMed] [Europe PMC] [Abstract]

"Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines."
Oncogene 21:3847-3854(2002) [PubMed] [Europe PMC] [Abstract]

"PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases."
J. Am. Soc. Nephrol. 14:1145-1153(2003) [PubMed] [Europe PMC] [Abstract]

"Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure."
J. Biol. Chem. 278:17114-17120(2003) [PubMed] [Europe PMC] [Abstract]

"PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle."
Arterioscler. Thromb. Vasc. Biol. 24:787-792(2004) [PubMed] [Europe PMC] [Abstract]

"Tissue plasminogen activator is a potent activator of PDGF-CC."
EMBO J. 23:3793-3802(2004) [PubMed] [Europe PMC] [Abstract]

"Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1."
J. Biol. Chem. 279:40289-40295(2004) [PubMed] [Europe PMC] [Abstract]

"Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family."
FEBS J. 272:5723-5741(2005) [PubMed] [Europe PMC] [Abstract]

"Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator."
J. Biol. Chem. 280:26856-26862(2005) [PubMed] [Europe PMC] [Abstract]

"Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts."
J. Cell. Physiol. 202:510-517(2005) [PubMed] [Europe PMC] [Abstract]

"Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma."
Proc. Natl. Acad. Sci. U.S.A. 102:3389-3394(2005) [PubMed] [Europe PMC] [Abstract]

"Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferation."
Am. J. Respir. Cell Mol. Biol. 34:746-753(2006) [PubMed] [Europe PMC] [Abstract]

"Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines."
Exp. Cell Res. 312:782-795(2006) [PubMed] [Europe PMC] [Abstract]

"PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines."
Invest. Ophthalmol. Vis. Sci. 48:5722-5732(2007) [PubMed] [Europe PMC] [Abstract]

"Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata."
Fertil. Steril. 89:468-471(2008) [PubMed] [Europe PMC] [Abstract]

"Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy."
Invest. Ophthalmol. Vis. Sci. 49:42-48(2008) [PubMed] [Europe PMC] [Abstract]