Platelet Derived Growth Factor Subunit B (PDGFB)

PDGF-B; PDGF2; SIS; SSV; C-sis; Simian Sarcoma Viral(v-sis)Oncogene Homolog; Platelet Derived Growth Factor Beta Polypeptide; Proto-oncogene c-Sis; Becaplermin

SPN	T906
HGNC	8800
MGI	97528
PubMed	11420709
RGD	3283
UniProt	P01127
Wiki	PDGFB

Platelet-derived growth factor subunit B is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.

Reference

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Science 225:636-639(1984) [PubMed] [Europe PMC] [Abstract]

"Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis."
Nature 316:748-750(1985) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor."
Nucleic Acids Res. 13:5007-5018(1985) [PubMed] [Europe PMC] [Abstract]

"Oncogenic potential of the human platelet-derived growth factor transcriptional unit."
Cold Spring Harb. Symp. Quant. Biol. 51:959-966(1986) [PubMed] [Europe PMC] [Abstract]

"Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit."
Proc. Natl. Acad. Sci. U.S.A. 83:2392-2396(1986) [PubMed] [Europe PMC] [Abstract]

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Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel human c-sis mRNA species is transcribed from a promoter in c-sis intron 1 and contains the code for an alternative PDGF B-like protein."
Nucleic Acids Res. 23:2815-2822(1995) [PubMed] [Europe PMC] [Abstract]

"Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma."
Nat. Genet. 15:95-98(1997) [PubMed] [Europe PMC] [Abstract]

"Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor."
Cell 37:123-129(1984) [PubMed] [Europe PMC] [Abstract]

"The human osteosarcoma cell line U-2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF-B chain."
FEBS Lett. 198:344-348(1986) [PubMed] [Europe PMC] [Abstract]

"Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus."
Nature 304:35-39(1983) [PubMed] [Europe PMC] [Abstract]

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Science 220:963-965(1983) [PubMed] [Europe PMC] [Abstract]

"The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor."
EMBO J. 3:921-928(1984) [PubMed] [Europe PMC] [Abstract]

"Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation."
EMBO J. 10:4113-4120(1991) [PubMed] [Europe PMC] [Abstract]

"Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF."
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"PDGF D, a novel protease-activated growth factor."
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EMBO J. 11:3921-3926(1992) [PubMed] [Europe PMC] [Abstract]

"Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex."
Proc. Natl. Acad. Sci. U.S.A. 107:11307-11312(2010) [PubMed] [Europe PMC] [Abstract]

"Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice."
Nat. Genet. 45:1077-1082(2013) [PubMed] [Europe PMC] [Abstract]