Gamma-Aminobutyric Acid B Receptor 1 (gABBR1)

GABAB(1e); GABABR1; GABA-BR1; GABBR1-3; GPRC3A; HGB1a; Gamma-aminobutyric acid type B receptor subunit 1

SPN	T893
HGNC	4070
MGI	1860139
PubMed	15685626
RGD	621537
UniProt	Q9UBS5
Wiki	GABBR1

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals.

The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

Reference

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Proc. Natl. Acad. Sci. U.S.A. 95:14991-14996(1998) [PubMed] [Europe PMC] [Abstract]

"Heterodimerization is required for the formation of a functional GABA(B) receptor."
Nature 396:679-682(1998) [PubMed] [Europe PMC] [Abstract]

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Neurogenetics 2:47-54(1998) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of human GABABR1 and its tissue distribution."
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"Characterization of gamma-aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor."
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"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

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"Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor."
J. Pharmacol. Exp. Ther. 293:460-467(2000) [PubMed] [Europe PMC] [Abstract]

"Role of heteromer formation in GABAB receptor function."
Science 283:74-77(1999) [PubMed] [Europe PMC] [Abstract]

"Marlin-1, a novel RNA-binding protein associates with GABA receptors."
J. Biol. Chem. 279:13934-13943(2004) [PubMed] [Europe PMC] [Abstract]

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"Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor."
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Nat. Neurosci. 15:970-978(2012) [PubMed] [Europe PMC] [Abstract]

"Structural mechanism of ligand activation in human GABA(B) receptor."
Nature 504:254-259(2013) [PubMed] [Europe PMC] [Abstract]

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