Corticotropin Releasing Hormone Receptor 1 (CRHR1)

CRF-R; CRF1; CRFR1; CRH-R1h; CRHR; CRHR1f; Corticotropin-releasing factor receptor 1

SPN	T892
HGNC	2357
MGI	88498
PubMed	19736354
RGD	61276
UniProt	P34998
Wiki	CRHR1

CRHR1) is a protein, also known as CRF₁, with the latter (CRF₁) now being the IUPHAR-recommended name. The corticotropin-releasing hormone receptor binds to corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress.CRF1 receptors in mice mediate ethanol enhancement of GABAergic synaptic transmission.

Variations in the CRHR1 gene is associated with enhanced response to inhaled corticosteroid therapy in asthma. CRF1 receptor antagonists are being actively studied as possible treatments for depression and anxiety.

Reference

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"Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]

"Role of SAP97 protein in the regulation of corticotropin-releasing factor receptor 1 endocytosis and extracellular signal-regulated kinase 1/2 signaling."
J. Biol. Chem. 288:15023-15034(2013) [PubMed] [Europe PMC] [Abstract]

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"NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist."
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"Structure of class B GPCR corticotropin-releasing factor receptor 1."
Nature 499:438-443(2013) [PubMed] [Europe PMC] [Abstract]