Formyl Peptide Receptor 1 (FPR1)

FMLP; FPR; fMet-Leu-Phe receptor; N-formylpeptide chemoattractant receptor

SPN	T881
HGNC	3826
MGI	107443
PubMed	12595898
RGD	1310883
UniProt	P21462
Wiki	FPR1

fMet-Leu-Phe receptor is a protein encoded by the FPR1 gene.Ozcelik et al. mapped the FPR1 gene to human chromosome 19 by Southern analysis of rodent/human somatic cell hybrids and use of a cDNA probe. An FPR-like gene was also identified on chromosome 19 . An FPR-like gene that mapped to chromosome 2 was found in fact to represent an interleukin 8 receptor. Bao et al. mapped the gene encoding the receptor for the chemotactic ligand FMLP to chromosome 19, using a panel of somatic cell hybrids. They identified 2 structural homologs of FPR that similarly mapped to chromosome 19. The structural homologs did not recognize the ligand FMLP, but were thought to represent chemotactic receptors. Bao et al. referred to them as orphan receptors and symbolized the genes FPRH1 and FPRH2.

Reference

"Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA."
Biochem. Biophys. Res. Commun. 168:1103-1109(1990) [PubMed] [Europe PMC] [Abstract]

"The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors."
Biochemistry 29:11123-11133(1990) [PubMed] [Europe PMC] [Abstract]

"Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor."
J. Biol. Chem. 266:12560-12567(1991) [PubMed] [Europe PMC] [Abstract]

"Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19."
Genomics 13:437-440(1992) [PubMed] [Europe PMC] [Abstract]

"Sequence and organization of the human N-formyl peptide receptor-encoding gene."
Gene 133:285-290(1993) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression."
Biochemistry 31:11595-11599(1992) [PubMed] [Europe PMC] [Abstract]

"Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor."
J. Biol. Chem. 274:29791-29795(1999) [PubMed] [Europe PMC] [Abstract]

"Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor."
J. Immunol. 172:6994-7001(2004) [PubMed] [Europe PMC] [Abstract]