Interleukin 12 Receptor Beta 2 (IL12Rb2)

IL12R-B2; IL12-RB2; RP11-102M16.1

SPN	T875
HGNC	5972
MGI	1270861
PubMed	18353079
RGD	620026
UniProt	Q99665
Wiki	IL12RB2

Interleukin 12 receptor, beta 2 subunit is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling.

The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.

Reference

"A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits."
Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of the human interleukin-12 receptor beta2-chain gene."
Immunogenetics 51:30-36(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Direct interaction of STAT4 with the IL-12 receptor."
Arch. Biochem. Biophys. 368:147-155(1999) [PubMed] [Europe PMC] [Abstract]

"Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus."
Biochem. Biophys. Res. Commun. 257:400-404(1999) [PubMed] [Europe PMC] [Abstract]

"Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling."
J. Biol. Chem. 274:1875-1878(1999) [PubMed] [Europe PMC] [Abstract]

"Selective expression of an interleukin-12 receptor component by human T helper 1 cells."
J. Exp. Med. 185:825-831(1997) [PubMed] [Europe PMC] [Abstract]

"SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit."
Biochem. Biophys. Res. Commun. 310:1188-1193(2003) [PubMed] [Europe PMC] [Abstract]

"Mutations of the IL-12 receptor beta2 chain gene in atopic subjects."
Biochem. Biophys. Res. Commun. 266:551-555(1999) [PubMed] [Europe PMC] [Abstract]