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Corticosteroid Binding Globulin (CBG)

SERPINA6; Transcortin; Serpin A6; Serpin Peptidase Inhibitor,Clade A,Member 6(Alpha-1 Antiproteinase; Antitrypsin)

Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.Transcortin is produced by the liver and is regulated by estrogens. Therefore, plasma transcortin levels increase during pregnancy, and are decreased in cirrhosis.
Corticosteroid-binding globulin is an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins T870Hu01 Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies MT870Hu22 Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
PT870Hu01 Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
LT870Hu71 Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits KET870Hu ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins T870Mu01 Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
PT870Mu01 Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits KET870Mu ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins T870Ra01 Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies MT870Ra24 Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
PT870Ra01 Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
LT870Ra76 Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits KET870Ra ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Corticosteroid Binding Globulin (CBG) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Corticosteroid Binding Globulin (CBG) Bioactivity
Antibodies NONE Monoclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Corticosteroid Binding Globulin (CBG) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Corticosteroid Binding Globulin (CBG) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Corticosteroid Binding Globulin (CBG) CLIA assay for Antigen Detection

Reference

"Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors."
Proc. Natl. Acad. Sci. U.S.A. 84:5153-5157(1987) [PubMed] [Europe PMC] [Abstract]

"Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors."
J. Steroid Biochem. 30:131-139(1988) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Comparative structural analyses of corticosteroid binding globulin."
J. Steroid Biochem. 29:213-220(1988) [PubMed] [Europe PMC] [Abstract]

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release."
J. Mol. Biol. 380:244-251(2008) [PubMed] [Europe PMC] [Abstract]

"A Leu-->His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol."
J. Steroid Biochem. Mol. Biol. 42:671-676(1992) [PubMed] [Europe PMC] [Abstract]

"Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93."
Steroids 58:275-277(1993) [PubMed] [Europe PMC] [Abstract]

"Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity."
J. Clin. Endocrinol. Metab. 85:361-367(2000) [PubMed] [Europe PMC] [Abstract]

"Haploinsufficiency of the SERPINA6 gene is associated with severe muscle fatigue: A de novo mutation in corticosteroid-binding globulin deficiency."
J. Neural Transm. 114:563-569(2007) [PubMed] [Europe PMC] [Abstract]