Acyl Carrier Protein, Mitochondrial (ACP)

NDUFAB1; CI-SDAP; SDAP; FASN2A; NADH-Ubiquinone Oxidoreductase 9.6 kDa Subunit

SPN	T865
HGNC	7694
MGI	1917566
PubMed	8016262
RGD	1305619
UniProt	O14561

The acyl carrier protein (ACP) is an important component in both fatty acid and polyketide biosynthesis with the growing chain bound during synthesis as a thiol ester at the distal thiol of a 4'-phosphopantethiene moiety. The protein is expressed in the inactive apo form and the 4'-phosphopantetheine moiety must be post-translationally attached to a conserved serine residue on the ACP by the action of holo-acyl carrier protein synthase (ACPS) a phosphopantetheinyl transferase.The multisubunit NADH:ubiquinone oxidoreductase (complex I) is the first enzyme complex in the electron transport chain of mitochondria.Runswick et al. (1991) reported that the bovine SDAP subunit of complex I is an acyl carrier protein. Loeffen et al. (1998) stated that GenBank represents the cDNA encoding the human homolog of SDAP.

Reference

"cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q."
Genomics 60:295-308(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini."
Proc. Natl. Acad. Sci. U.S.A. 106:19310-19315(2009) [PubMed] [Europe PMC] [Abstract]

"The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of RSGI RUH-059, an ACP domain of acyl carrier protein, mitochondrial from human."
Submitted (OCT-2006) to the PDB data bank