Synaptosomal Associated Protein 25kDa (SNAP25)
RIC4; SEC9; SNAP; SUP; Super protein; Resistance To Inhibitors Of Cholinesterase 4 Homolog
The SNAP-25 protein is a component of the SNARE complex, which is proposed to account for the specificity of membrane fusion and to directly execute fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together.SNAP-25 is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP-25 is a Q-SNARE protein contributing two α-helices in the formation of the exocytotic fusion complex in neurons where it assembles with syntaxin-1 and synaptobrevin. SNAP-25 inhibits P/Q- and L-type voltage-gated calcium channels located presynaptically. and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP-25 decreases the Ca2+ responsiveness.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT861Hu01 | Recombinant Synaptosomal Associated Protein 25kDa (SNAP25) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT861Hu01 | Monoclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IP. |
| PAT861Hu01 | Polyclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT861Hu01 | CLIA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | CLIA assay for Antigen Detection |
| ELT861Hu01 | ELISA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT861Mu01 | Recombinant Synaptosomal Associated Protein 25kDa (SNAP25) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT861Mu01 | Monoclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IP. |
| PAT861Mu01 | Polyclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT861Mu01 | CLIA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | CLIA assay for Antigen Detection |
| ELT861Mu01 | ELISA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT861Ra01 | Recombinant Synaptosomal Associated Protein 25kDa (SNAP25) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT861Ra01 | Monoclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IP. |
| PAT861Ra01 | Polyclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT861Ra01 | CLIA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | CLIA assay for Antigen Detection |
| ELT861Ra01 | ELISA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT861Ca01 | Recombinant Synaptosomal Associated Protein 25kDa (SNAP25) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT861Ca01 | Monoclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IP. |
| PAT861Ca01 | Polyclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT861Ca01 | CLIA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | CLIA assay for Antigen Detection |
| ELT861Ca01 | ELISA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT861Po01 | Recombinant Synaptosomal Associated Protein 25kDa (SNAP25) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT861Po01 | Monoclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IP. |
| PAT861Po01 | Polyclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT861Po01 | CLIA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | CLIA assay for Antigen Detection |
| ELT861Po01 | ELISA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT861Bo01 | Recombinant Synaptosomal Associated Protein 25kDa (SNAP25) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT861Bo01 | Monoclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IP. |
| PAT861Bo01 | Polyclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT861Bo01 | CLIA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | CLIA assay for Antigen Detection |
| ELT861Bo01 | ELISA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT861Rb01 | Recombinant Synaptosomal Associated Protein 25kDa (SNAP25) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT861Rb01 | Monoclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IP. |
| PAT861Rb01 | Polyclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT861Rb01 | CLIA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | CLIA assay for Antigen Detection |
| ELT861Rb01 | ELISA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT861Mo01 | Recombinant Synaptosomal Associated Protein 25kDa (SNAP25) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT861Mo01 | Monoclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IP. |
| PAT861Mo01 | Polyclonal Antibody to Synaptosomal Associated Protein 25kDa (SNAP25) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT861Mo01 | CLIA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | CLIA assay for Antigen Detection |
| ELT861Mo01 | ELISA Kit for Synaptosomal Associated Protein 25kDa (SNAP25) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25."
Gene 139:291-292(1994) [PubMed] [Europe PMC] [Abstract]
"Cloning and sequence analysis of the human SNAP25 cDNA."
Gene 145:313-314(1994) [PubMed] [Europe PMC] [Abstract]
"Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2."
Biochem. J. 317:945-954(1996) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"SNAP-25 is also an iron-sulfur protein."
FEBS Lett. 582:1431-1436(2008) [PubMed] [Europe PMC] [Abstract]
"The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth."
Mol. Psychiatry 15:204-215(2010)
"Three-dimensional structure of the complexin/SNARE complex."
Neuron 33:397-409(2002) [PubMed] [Europe PMC] [Abstract]