Cocaine And Amphetamine Regulated Transcript (CART)
CARTPT
CART is a neuropeptide which also serves as a neurotransmitter. It produces similar behaviour in animals to cocaine and amphetamine, but conversely blocks the effects of cocaine when they are co-administered. The peptide is found in several areas, among them the ventral tegmental area (VTA) of the brain. When CART is injected into rat VTA, increased locomotor activity is seen, which is one of the signs of "central stimulation" caused by substances such as cocaine and amphetamine. The rats also tended to return to the place where they had been injected. This is called conditioned place preference and is seen after injection of cocaine. CART is found at the same locations where cocaine and methamphetamine mainly act in the brain. This has led to speculation that CART could be an "endogenous cocaine".
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT859Hu01 | Recombinant Cocaine And Amphetamine Regulated Transcript (CART) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT859Hu01 | Monoclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IP. |
| PAT859Hu01 | Polyclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT859Hu01 | CLIA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | CLIA assay for Antigen Detection |
| ELT859Hu01 | ELISA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT859Mu01 | Recombinant Cocaine And Amphetamine Regulated Transcript (CART) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT859Mu01 | Monoclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IP. |
| PAT859Mu01 | Polyclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT859Mu01 | CLIA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | CLIA assay for Antigen Detection |
| ELT859Mu01 | ELISA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT859Ra01 | Recombinant Cocaine And Amphetamine Regulated Transcript (CART) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT859Ra01 | Monoclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IP. |
| PAT859Ra01 | Polyclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT859Ra01 | CLIA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | CLIA assay for Antigen Detection |
| ELT859Ra01 | ELISA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT859Ca01 | Recombinant Cocaine And Amphetamine Regulated Transcript (CART) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT859Ca01 | Monoclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IP. |
| PAT859Ca01 | Polyclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT859Ca01 | CLIA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | CLIA assay for Antigen Detection |
| ELT859Ca01 | ELISA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT859Po01 | Recombinant Cocaine And Amphetamine Regulated Transcript (CART) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT859Po01 | Monoclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IP. |
| PAT859Po01 | Polyclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT859Po01 | CLIA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | CLIA assay for Antigen Detection |
| ELT859Po01 | ELISA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT859Bo01 | Recombinant Cocaine And Amphetamine Regulated Transcript (CART) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT859Bo01 | Monoclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IP. |
| PAT859Bo01 | Polyclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT859Bo01 | CLIA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | CLIA assay for Antigen Detection |
| ELT859Bo01 | ELISA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT859Rb01 | Recombinant Cocaine And Amphetamine Regulated Transcript (CART) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT859Rb01 | Monoclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IP. |
| PAT859Rb01 | Polyclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT859Rb01 | CLIA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | CLIA assay for Antigen Detection |
| ELT859Rb01 | ELISA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT859Mo01 | Recombinant Cocaine And Amphetamine Regulated Transcript (CART) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT859Mo01 | Monoclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IP. |
| PAT859Mo01 | Polyclonal Antibody to Cocaine And Amphetamine Regulated Transcript (CART) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT859Mo01 | CLIA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | CLIA assay for Antigen Detection |
| ELT859Mo01 | ELISA Kit for Cocaine And Amphetamine Regulated Transcript (CART) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript."
Gene 169:241-245(1996) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Hypothalamic CART is a new anorectic peptide regulated by leptin."
Nature 393:72-76(1998) [PubMed] [Europe PMC] [Abstract]
"Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold."
Biochemistry 40:9082-9088(2001) [PubMed] [Europe PMC] [Abstract]
"The CART gene and human obesity: mutational analysis and population genetics."
Diabetes 49:872-875(2000) [PubMed] [Europe PMC] [Abstract]
"Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family."
Diabetes 50:2157-2160(2001) [PubMed] [Europe PMC] [Abstract]