Collagen Type I Alpha 1 (COL1a1)
COL-1A1; COL1-A1; COL1A-1; OI4; Collagen Alpha-1(I)chain
Collagen, type I, alpha 1 is the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage.
The COL1A1 gene produces a component of type I collagen, called the pro-alpha1(I) chain. This chain combines with another pro-alpha1(I) chain and also with a pro-alpha2(I) chain (produced by the COL1A2 gene) to make a molecule of type I procollagen. These triple-stranded, rope-like procollagen molecules must be processed by enzymes outside the cell. Once these molecules are processed, they arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong mature type I collagen fibers.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPT858Hu01 | Recombinant Collagen Type I Alpha 1 (COL1a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAT858Hu01 | Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IP. |
PAT858Hu01 | Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IF. | |
Assay Kits | CLT858Hu01 | CLIA Kit for Collagen Type I Alpha 1 (COL1a1) | CLIA assay for Antigen Detection |
ELT858Hu01 | ELISA Kit for Collagen Type I Alpha 1 (COL1a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPT858Mu01 | Recombinant Collagen Type I Alpha 1 (COL1a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAT858Mu01 | Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IP. |
PAT858Mu01 | Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IF. | |
Assay Kits | CLT858Mu01 | CLIA Kit for Collagen Type I Alpha 1 (COL1a1) | CLIA assay for Antigen Detection |
ELT858Mu01 | ELISA Kit for Collagen Type I Alpha 1 (COL1a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPT858Ra01 | Recombinant Collagen Type I Alpha 1 (COL1a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAT858Ra01 | Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IP. |
PAT858Ra01 | Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IF. | |
Assay Kits | CLT858Ra01 | CLIA Kit for Collagen Type I Alpha 1 (COL1a1) | CLIA assay for Antigen Detection |
ELT858Ra01 | ELISA Kit for Collagen Type I Alpha 1 (COL1a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPT858Ca01 | Recombinant Collagen Type I Alpha 1 (COL1a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAT858Ca01 | Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IP. |
PAT858Ca01 | Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IF. | |
Assay Kits | CLT858Ca01 | CLIA Kit for Collagen Type I Alpha 1 (COL1a1) | CLIA assay for Antigen Detection |
ELT858Ca01 | ELISA Kit for Collagen Type I Alpha 1 (COL1a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPT858Po01 | Recombinant Collagen Type I Alpha 1 (COL1a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAT858Po01 | Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IP. |
PAT858Po01 | Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IF. | |
Assay Kits | CLT858Po01 | CLIA Kit for Collagen Type I Alpha 1 (COL1a1) | CLIA assay for Antigen Detection |
ELT858Po01 | ELISA Kit for Collagen Type I Alpha 1 (COL1a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPT858Bo01 | Recombinant Collagen Type I Alpha 1 (COL1a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAT858Bo01 | Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IP. |
PAT858Bo01 | Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IF. | |
Assay Kits | CLT858Bo01 | CLIA Kit for Collagen Type I Alpha 1 (COL1a1) | CLIA assay for Antigen Detection |
ELT858Bo01 | ELISA Kit for Collagen Type I Alpha 1 (COL1a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPT858Rb01 | Recombinant Collagen Type I Alpha 1 (COL1a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAT858Rb01 | Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IP. |
PAT858Rb01 | Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IF. | |
Assay Kits | CLT858Rb01 | CLIA Kit for Collagen Type I Alpha 1 (COL1a1) | CLIA assay for Antigen Detection |
ELT858Rb01 | ELISA Kit for Collagen Type I Alpha 1 (COL1a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | RPT858Mo01 | Recombinant Collagen Type I Alpha 1 (COL1a1) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | MAT858Mo01 | Monoclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IP. |
PAT858Mo01 | Polyclonal Antibody to Collagen Type I Alpha 1 (COL1a1) | WB; IHC; ICC; IF. | |
Assay Kits | CLT858Mo01 | CLIA Kit for Collagen Type I Alpha 1 (COL1a1) | CLIA assay for Antigen Detection |
ELT858Mo01 | ELISA Kit for Collagen Type I Alpha 1 (COL1a1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type I: identification of common sequences of null-allele mutations."
Am. J. Hum. Genet. 62:98-110(1998) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Complete nucleotide sequence of the region encompassing the first twenty-five exons of the human pro alpha 1(I) collagen gene (COL1A1)."
Gene 67:105-115(1988) [PubMed] [Europe PMC] [Abstract]
"Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen."
Biochem. J. 253:919-922(1988) [PubMed] [Europe PMC] [Abstract]
"Human pro alpha 1(I) collagen gene structure reveals evolutionary conservation of a pattern of introns and exons."
Nature 310:337-340(1984) [PubMed] [Europe PMC] [Abstract]
"DNA sequences in the first intron of the human pro-alpha 1(I) collagen gene enhance transcription."
J. Biol. Chem. 262:15151-15157(1987) [PubMed] [Europe PMC] [Abstract]
"Fine structural analysis of the human pro-alpha 1 (I) collagen gene. Promoter structure, AluI repeats, and polymorphic transcripts."
J. Biol. Chem. 260:2315-2320(1985) [PubMed] [Europe PMC] [Abstract]
"Regulatory elements in the first intron contribute to transcriptional control of the human alpha 1(I) collagen gene."
Proc. Natl. Acad. Sci. U.S.A. 84:8869-8873(1987) [PubMed] [Europe PMC] [Abstract]
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J. Biol. Chem. 265:6312-6317(1990) [PubMed] [Europe PMC] [Abstract]
"A base substitution in the exon of a collagen gene causes alternative splicing and generates a structurally abnormal polypeptide in a patient with Ehlers-Danlos syndrome type VII."
EMBO J. 8:1705-1710(1989) [PubMed] [Europe PMC] [Abstract]
"Isolation and characterization of the cyanogen bromide peptides from the alpha 1 and alpha 2 chains of human skin collagen."
Biochemistry 9:4699-4706(1970) [PubMed] [Europe PMC] [Abstract]
"A critical crosslink region in human-bone-derived collagen type I. Specific cleavage site at residue Leu95."
Eur. J. Biochem. 192:153-159(1990) [PubMed] [Europe PMC] [Abstract]
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J. Biol. Chem. 245:5042-5048(1970) [PubMed] [Europe PMC] [Abstract]
"Segmental amplification of the entire helical and telopeptide regions of the cDNA for human alpha 1 (I) collagen."
Matrix 10:124-130(1990) [PubMed] [Europe PMC] [Abstract]
"Nucleotide sequences of complementary deoxyribonucleic acids for the pro alpha 1 chain of human type I procollagen. Statistical evaluation of structures that are conserved during evolution."
Biochemistry 22:5213-5223(1983) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of five overlapping cDNAs specific for the human pro alpha 1(I) collagen chain."
Nucleic Acids Res. 10:5925-5934(1982) [PubMed] [Europe PMC] [Abstract]
"Multiexon deletion in an osteogenesis imperfecta variant with increased type III collagen mRNA."
J. Biol. Chem. 260:691-694(1985) [PubMed] [Europe PMC] [Abstract]
"Intron-mediated recombination may cause a deletion in an alpha 1 type I collagen chain in a lethal form of osteogenesis imperfecta."
Proc. Natl. Acad. Sci. U.S.A. 82:2870-2874(1985) [PubMed] [Europe PMC] [Abstract]
"Variable expression of osteogenesis imperfecta in a nuclear family is explained by somatic mosaicism for a lethal point mutation in the alpha 1(I) gene (COL1A1) of type I collagen in a parent."
Am. J. Hum. Genet. 46:1034-1040(1990) [PubMed] [Europe PMC] [Abstract]
"Severe (type III) osteogenesis imperfecta due to glycine substitutions in the central domain of the collagen triple helix."
Hum. Mol. Genet. 3:2201-2206(1994) [PubMed] [Europe PMC] [Abstract]