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Calpain 3 (CAPN3)

CANPL3; p94; LGMD2; LGMD2A; nCL1; Calcium-activated neutral proteinase 3; Muscle-specific calcium-activated neutral protease 3; New calpain 1

Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. CAPN3 encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin.Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. In melanocytic cells CAPN3 gene expression may be regulated by MITF.Defects in CAPN3 are the cause of limb-girdle muscular dystrophy type 2A (LGMD2A). LGMD2A is an autosomal recessive degenerative myopathy characterized by progressive symmetrical atrophy and weakness of the proximal limb muscles and elevated serum creatine kinase.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins T852Hu01 Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies MT852Hu22 Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
PT852Hu01 Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits KET852Hu ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Calpain 3 (CAPN3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Calpain 3 (CAPN3) Bioactivity
Antibodies NONE Monoclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Calpain 3 (CAPN3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Calpain 3 (CAPN3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Calpain 3 (CAPN3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Calpain 3 (CAPN3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Calpain 3 (CAPN3) CLIA assay for Antigen Detection

Reference

"Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A."
Cell 81:27-40(1995) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle."
J. Biol. Chem. 264:20106-20111(1989) [PubMed] [Europe PMC] [Abstract]

"The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules."
J. Mol. Biol. 333:951-964(2003) [PubMed] [Europe PMC] [Abstract]

"Calpainopathy -- a survey of mutations and polymorphisms."
Am. J. Hum. Genet. 64:1524-1540(1999) [PubMed] [Europe PMC] [Abstract]

"Interactions with M-band titin and calpain 3 link myospryn (CMYA5) to tibial and limb-girdle muscular dystrophies."
J. Biol. Chem. 285:30304-30315(2010) [PubMed] [Europe PMC] [Abstract]

"Juvenile limb-girdle muscular dystrophy. Clinical, histopathological and genetic data from a small community living in the Reunion island."
Brain 119:295-308(1996) [PubMed] [Europe PMC] [Abstract]

"Multiple independent molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins."
Am. J. Hum. Genet. 60:1128-1138(1997) [PubMed] [Europe PMC] [Abstract]

"A biochemical, genetic, and clinical survey of autosomal recessive limb girdle muscular dystrophies in Turkey."
Ann. Neurol. 42:222-229(1997) [PubMed] [Europe PMC] [Abstract]

"Limb-girdle muscular dystrophy in Guipuzcoa (Basque Country, Spain)."
Brain 121:1735-1747(1998) [PubMed] [Europe PMC] [Abstract]

"A small in-frame deletion within the protease domain of muscle-specific calpain, p94 causes early-onset limb-girdle muscular dystrophy 2A."
Hum. Mutat. Suppl. 1:S298-S300(1998) [PubMed] [Europe PMC] [Abstract]

"Pseudometabolic expression and phenotypic variability of calpain deficiency in two siblings."
Muscle Nerve 21:1078-1080(1998) [PubMed] [Europe PMC] [Abstract]

"Clinical, pathological, and genetic features of limb-girdle muscular dystrophy type 2A with new calpain 3 gene mutations in seven patients from three Japanese families."
Muscle Nerve 21:1493-1501(1998) [PubMed] [Europe PMC] [Abstract]