Cathepsin V (CTSV)

CTS-L2; CTSL2; CATL2; CTSU; CTS-V; Cathepsin L2

SPN	T842
HGNC	2538
MGI	88564
PubMed	10029531
UniProt	O60911
Wiki	Cathepsin_L2

Cathepsin L2 is a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.

The predicted 334-amino acid protein was designated cathepsin L2 because it shared 78% sequence identity with cathepsin L. Cathepsin L2 contains a 17-amino acid signal sequence and a 96-amino acid proregion. Recombinant protein displayed cysteine proteinase activity in vitro, with substrate specificity similar to that of cathepsin L. Northern blot analysis revealed that cathepsin L2 is expressed as a 1.8-kb mRNA predominantly in thymus and testis.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	T842Hu01	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	MT842Hu22	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	PT842Hu01	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	KET842Hu	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Cathepsin V (CTSV)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Cathepsin V (CTSV)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Cathepsin V (CTSV)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Cathepsin V (CTSV)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Cathepsin V (CTSV)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Cathepsin V (CTSV)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Cathepsin V (CTSV)	CLIA assay for Antigen Detection

Reference

"Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas."
Cancer Res. 58:1624-1630(1998) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium."
Invest. Ophthalmol. Vis. Sci. 39:1789-1796(1998) [PubMed] [Europe PMC] [Abstract]

"Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization."
Biochemistry 38:2377-2385(1999) [PubMed] [Europe PMC] [Abstract]

"Genomic organization and chromosomal localization of the human cathepsin L2 gene."
DNA Res. 6:137-140(1999) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Determination of cathepsin V activity and intracellular trafficking by N-glycosylation."
FEBS Lett. 586:3601-3607(2012) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human cathepsin V."
Biochemistry 39:12543-12551(2000) [PubMed] [Europe PMC] [Abstract]

Erratum
Biochemistry 40:4200-4200(2001)