Galectin 14 (GAL14)

LGALS14; CLC2; PPL13; Placental Protein 13-Like; Lectin,Galactoside-Binding Soluble 14; Charcot-Leyden crystal protein 2

SPN	T824
HGNC	30054
PubMed	11839756
UniProt	Q8TCE9

also known as placental protein 13-like (PPL13), belongs to a family of proteins called galectins. Galectins are lectins containing 1 or 2 carbohydrate recognition domains (CRDs), and they show calcium-independent binding of beta-galactoside. Yang et al. (2002) cloned GAL14 from a fetal brain cDNA library. The deduced 139-amino acid protein has a calculated molecular mass of 16.1 kD. GAL14 contains a single CRD domain and several putative phosphorylation sites, but no signal peptide or targeting signals. The GAL14 protein shares 78%, 67%, and 54% amino acid identity with the PP13, galectin-10 (CLC; 153310), and sheep ovgal11 proteins, respectively. It is expressed intracellularly in placenta and eosinophils and is released by eosinophils following allergen stimulation. Galectin-14 may be involved in the development of allergic inflammation.

Reference

"Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta."
Biochim. Biophys. Acta 1574:407-411(2002) [PubMed] [Europe PMC] [Abstract]

"A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death."
Proc. Natl. Acad. Sci. U.S.A. 106:9731-9736(2009) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]