Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 (CEACAM1)

CD66a; BGP; BGP1; BGPI; CD66-A; Biliary Glycoprotein

SPN	T806
HGNC	1814
MGI	1347245
PubMed	17446843
RGD	67396
UniProt	P13688
Wiki	CEACAM1

CEACAM1is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19.

Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup.

Reference

"Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen."
Proc. Natl. Acad. Sci. U.S.A. 85:6959-6963(1988) [PubMed] [Europe PMC] [Abstract]

Erratum
Proc. Natl. Acad. Sci. U.S.A. 86:1668-1668(1989)

"Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family."
J. Cell Biol. 108:267-276(1989) [PubMed] [Europe PMC] [Abstract]

"Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library."
Biochem. Biophys. Res. Commun. 176:578-585(1991) [PubMed] [Europe PMC] [Abstract]

"Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins."
Mol. Cell. Biol. 13:1273-1282(1993) [PubMed] [Europe PMC] [Abstract]

"CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant."
Blood 84:200-210(1994) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas."
Eur. J. Biochem. 223:529-541(1994) [PubMed] [Europe PMC] [Abstract]

"Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene."
Eur. J. Biochem. 231:104-114(1995) [PubMed] [Europe PMC] [Abstract]

"Redefined nomenclature for members of the carcinoembryonic antigen family."
Exp. Cell Res. 252:243-249(1999) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae."
Acta Crystallogr. D 62:971-979(2006) [PubMed] [Europe PMC] [Abstract]