Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3)
CD66d; CEA; CD66-D; CGM1; W264; W282; Carcinoembryonic antigen CGM1
CEACAM3is a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT805Hu01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT805Hu01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IP. |
| PAT805Hu01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT805Hu01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | CLIA assay for Antigen Detection |
| ELT805Hu01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT805Mu01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT805Mu01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IP. |
| PAT805Mu01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT805Mu01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | CLIA assay for Antigen Detection |
| ELT805Mu01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT805Ra01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT805Ra01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IP. |
| PAT805Ra01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT805Ra01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | CLIA assay for Antigen Detection |
| ELT805Ra01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT805Ca01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT805Ca01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IP. |
| PAT805Ca01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT805Ca01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | CLIA assay for Antigen Detection |
| ELT805Ca01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT805Po01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT805Po01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IP. |
| PAT805Po01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT805Po01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | CLIA assay for Antigen Detection |
| ELT805Po01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT805Bo01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT805Bo01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IP. |
| PAT805Bo01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT805Bo01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | CLIA assay for Antigen Detection |
| ELT805Bo01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT805Rb01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT805Rb01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IP. |
| PAT805Rb01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT805Rb01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | CLIA assay for Antigen Detection |
| ELT805Rb01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT805Mo01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT805Mo01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IP. |
| PAT805Mo01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT805Mo01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | CLIA assay for Antigen Detection |
| ELT805Mo01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 3 (CEACAM3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning of nonspecific cross-reacting antigens in human granulocytes."
J. Biol. Chem. 266:11810-11817(1991) [PubMed] [Europe PMC] [Abstract]
"Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family."
Eur. J. Biochem. 214:27-35(1993) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of three new genes and estimation of the size of the carcinoembryonic antigen family."
Genomics 14:384-390(1992) [PubMed] [Europe PMC] [Abstract]
"The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes."
Biochem. Biophys. Res. Commun. 289:191-197(2001) [PubMed] [Europe PMC] [Abstract]
"Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor."
Mol. Microbiol. 49:623-637(2003) [PubMed] [Europe PMC] [Abstract]
"Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens."
J. Exp. Med. 199:35-46(2004) [PubMed] [Europe PMC] [Abstract]