Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6)
CD66c; NCA; CD66-C; CEAL; Non-Specific Cross Reacting Antigen; Normal cross-reacting antigen
- CEACAM6 acted as a receptor for AIEC adhesion and was upregulated in the ileal mucosa of CD patients compared to colonic mucosa or to controls. In vitro studies showed increased CEACAM6 expression in cultured intestinal epithelial cells after IFN-gamma or TNF-alpha stimulation and after infection with AIEC. Carcinoembryonic antigen (CEA) is one of the most widely used tumor markers in serum immunoassay determinations of carcinoma.
- CEACAM6 blocked adenovirus trafficking to the nucleus through the SRC pathway, interfering with cancer cell cytoskeleton and reducing adenoviral infection. Knockdown of CEACAM6 with small interfering RNA significantly increased adenovirus replication and antitumor efficacy of oncolytic adenovirus in a mouse xenograft tumor model.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT803Hu01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT803Hu01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IP. |
| PAT803Hu01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT803Hu01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | CLIA assay for Antigen Detection |
| ELT803Hu01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT803Mu01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT803Mu01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IP. |
| PAT803Mu01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT803Mu01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | CLIA assay for Antigen Detection |
| ELT803Mu01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT803Ra01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT803Ra01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IP. |
| PAT803Ra01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT803Ra01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | CLIA assay for Antigen Detection |
| ELT803Ra01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT803Ca01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT803Ca01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IP. |
| PAT803Ca01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT803Ca01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | CLIA assay for Antigen Detection |
| ELT803Ca01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT803Po01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT803Po01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IP. |
| PAT803Po01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT803Po01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | CLIA assay for Antigen Detection |
| ELT803Po01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT803Bo01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT803Bo01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IP. |
| PAT803Bo01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT803Bo01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | CLIA assay for Antigen Detection |
| ELT803Bo01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT803Rb01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT803Rb01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IP. |
| PAT803Rb01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT803Rb01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | CLIA assay for Antigen Detection |
| ELT803Rb01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT803Mo01 | Recombinant Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT803Mo01 | Monoclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IP. |
| PAT803Mo01 | Polyclonal Antibody to Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT803Mo01 | CLIA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | CLIA assay for Antigen Detection |
| ELT803Mo01 | ELISA Kit for Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 (CEACAM6) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains."
Genomics 3:59-66(1988) [PubMed] [Europe PMC] [Abstract]
"Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence."
Biochem. Biophys. Res. Commun. 150:89-96(1988) [PubMed] [Europe PMC] [Abstract]
"Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen."
J. Biol. Chem. 263:3202-3207(1988) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]