Carcinoembryonic Antigen Related Cell Adhesion Molecule 8 (CEACAM8)

CD67; CD66-B; CD66b; CGM6; NCA95; Carcinoembryonic antigen CGM6; Non-specific cross-reacting antigen NCA-95

SPN	T802
HGNC	1820
PubMed	17909799
UniProt	P31997
Wiki	CEACAM8

CEACAM family members are a set of widely expressed proteins involved in several biological functions, including cell adhesion, migration, signal transduction, and the regulation of gene expression. Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) also known as CD66b (Cluster of Differentiation 66b)Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion. It is normally produced during fetal development, but the production of CEA stops before birth. Therefore, it is not usually present in the blood of healthy adults, although levels are raised in heavy smokers.It was found that serum from individuals with colorectal carcinoma, gastric carcinoma, pancreatic carcinoma, lung carcinoma and breast carcinoma, as well as individuals with medullary thyroid carcinoma, had higher levels of CEA than healthy individuals.

Reference

"Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow."
Cancer Res. 50:6534-6539(1990) [PubMed] [Europe PMC] [Abstract]

"Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family."
Biochem. Biophys. Res. Commun. 166:1063-1071(1990) [PubMed] [Europe PMC] [Abstract]

"Identification of three new genes and estimation of the size of the carcinoembryonic antigen family."
Genomics 14:384-390(1992) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes."
Blood 91:663-672(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the first Ig-like domain of human carcinoembryonic antigen related cell adhesion molecule 8."
Submitted (MAY-2007) to the PDB data bank