Poly ADP Ribose Polymerase 4 (PARP4)

ADPRTL1; ARTD4; PARPL; PH5P; VAULT3; VPARP; P193; VWA5C; von Willebrand Factor A Domain Containing 5C; ADP-ribosyltransferase diphtheria toxin-like 4; Vault polymerase

SPN	T797
HGNC	271
MGI	2685589
PubMed	10644454
RGD	1310524
UniProt	Q9UKK3
Wiki	PARP4

Poly [ADP-ribose] polymerase 4 is an enzyme encoded by the PARP4 gene.This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction.

This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.

Reference

"The 193 kDa vault protein, VPARP, is a novel poly(ADP-ribose) polymerase."
J. Cell Biol. 146:917-928(1999) [PubMed] [Europe PMC] [Abstract]

"Identification of a novel gene (ADPRTL1) encoding a potential poly(ADP-ribosyl)transferase protein."
Genomics 62:533-536(1999) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
DNA Res. 3:17-24(1996) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

"The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?"
FEBS Lett. 446:6-8(1999) [PubMed] [Europe PMC] [Abstract]

"Vaults and telomerase share a common subunit, TEP1."
J. Biol. Chem. 274:32712-32717(1999) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]