Tankyrase 1 (TNKS1)
TNKS; ARTD5; PARPL; PARP-5a; PARP5A; TIN1; TINF1; TNKS-1; ADP-ribosyltransferase diphtheria toxin-like 5; TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase
Tankyrase 1, a human telomeric poly(ADP-ribose) polymerase, was originally identified through its interaction with TRF1, a negative regulator of telomere length. Tankyrase 1 ADP-ribosylates TRF1 in vitro, and its overexpression induces telomere elongation in human cancer cells. Surprisingly, dissection of this domain reveals multiple discrete and overlapping binding sites for TRF1 and TAB182. Five well conserved ankyrin repeat clusters in tankyrase 1. Although each of the five ankyrin repeat clusters independently binds to TRF1, only three of the five bind toTAB182. These findings suggest that tankyrase 1 may act as a scaffold for large molecular mass complexes made up of multiple binding proteins. Potential roles for tankyrase 1-mediated higher order complexes at telomeres and at other subcellular sites.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | T795Hu01 | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | MT795Hu22 | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| PT795Hu01 | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | KET795Hu | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tankyrase 1 (TNKS1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tankyrase 1 (TNKS1) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tankyrase 1 (TNKS1) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tankyrase 1 (TNKS1) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tankyrase 1 (TNKS1) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tankyrase 1 (TNKS1) | CLIA assay for Antigen Detection |
Reference
"Tankyrase, a poly(ADP-ribose) polymerase at human telomeres."
Science 282:1484-1487(1998) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes."
J. Cell Sci. 112:3649-3656(1999) [PubMed] [Europe PMC] [Abstract]
"Tankyrase is a Golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles."
J. Biol. Chem. 275:38437-38444(2000) [PubMed] [Europe PMC] [Abstract]
"Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres."
Mol. Cell. Biol. 22:332-342(2002) [PubMed] [Europe PMC] [Abstract]
"POT1 as a terminal transducer of TRF1 telomere length control."
Nature 423:1013-1018(2003) [PubMed] [Europe PMC] [Abstract]
"NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis."
Biochem. J. 391:177-184(2005) [PubMed] [Europe PMC] [Abstract]
"Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling."
Nature 461:614-620(2009) [PubMed] [Europe PMC] [Abstract]
"Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
"RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."
Nat. Cell Biol. 13:623-629(2011) [PubMed] [Europe PMC] [Abstract]
"Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling."
PLoS ONE 6:E22595-E22595(2011) [PubMed] [Europe PMC] [Abstract]
"Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation."
Mol. Cell 47:694-706(2012) [PubMed] [Europe PMC] [Abstract]
"Proteasome regulation by ADP-ribosylation."
Cell 153:614-627(2013) [PubMed] [Europe PMC] [Abstract]
"Zinc binding catalytic domain of human tankyrase 1."
J. Mol. Biol. 379:136-145(2008) [PubMed] [Europe PMC] [Abstract]