Glutathione Peroxidase 3, Plasma (GPX3)

GSHPX3; GPx-P; GSHPx-P; GPXP; Plasma glutathione peroxidase; Extracellular glutathione peroxidase

SPN	T791
HGNC	4555
MGI	105102
PubMed	23221387
RGD	69224
UniProt	P22352
Wiki	GPX3

It has been reported thatGPX3 protects from CD95-induced apoptosis in cultured breast cancer cells and inhibits 5-lipoxygenase in blood cells, and its overexpression delays endothelial cell growth and increases resistance to toxic challenges. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Reference

"Primary structure of human plasma glutathione peroxidase deduced from cDNA sequences."
J. Biochem. 108:145-148(1990) [PubMed] [Europe PMC] [Abstract]

"Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung, and breast in humans and rodents."
Blood 79:3233-3238(1992) [PubMed] [Europe PMC] [Abstract]

"The human plasma glutathione peroxidase-encoding gene: organization, sequence and localization to chromosome 5q32."
Gene 145:293-297(1994) [PubMed] [Europe PMC] [Abstract]

"Differential induction of extracellular glutathione peroxidase and nitric oxide synthase 2 in airways of healthy individuals exposed to 100% O(2) or cigarette smoke."
Am. J. Respir. Cell Mol. Biol. 23:350-354(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization and partial amino acid sequence of human plasma glutathione peroxidase."
Arch. Biochem. Biophys. 286:330-336(1991) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human glutathione peroxidase 3 (selenocysteine to glycine mutant)."
Submitted (SEP-2007) to the PDB data bank