Arginyl tRNA Synthetase (RARS)

ArgRS; DALRD1; Arginine tRNA Ligase 1,Cytoplasmic

SPN	T786
HGNC	9870
MGI	1914297
PubMed	19187230
RGD	1309215
UniProt	P54136
Wiki	RARS_(gene

Arginyl-tRNA synthetase, cytoplasmic is an enzyme encoded by the RARS gene.Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family.Knockdown of rrt1, and of most other genes encoding aminoacyl-tRNA synthetases, rescued animals from hypoxia-induced death, and the level of hypoxia resistance was inversely correlated with translation rate. The unfolded protein response was induced by hypoxia and was required for the hypoxia resistance of the reduction-of-function mutant of rrt1.

Reference

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"Two forms of human cytoplasmic arginyl-tRNA synthetase produced from two translation initiations by a single mRNA."
Biochemistry 45:1338-1344(2006) [PubMed] [Europe PMC] [Abstract]

"Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines."
J. Cell. Physiol. 212:293-297(2007) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
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"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

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"Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures."
Am. J. Hum. Genet. 94:547-558(2014) [PubMed] [Europe PMC] [Abstract]

"Mutations in RARS cause hypomyelination."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]