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Leucyl tRNA Synthetase (LARS)

LEURS; LARS1; LEUS; RNTLS; Leucine tRNA Ligase 1,Cytoplasmic

Leucyl-tRNA synthetase, cytoplasmic isa cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.Following the system used for isoenzymes encoded by nuclear genes, in which 1 is used to designate the cytoplasmic or soluble form and 2 is used to designate the mitochondrial form and SOD2, cytoplasmic LARS might be referred to as LARS1, and the mitochondrial form as LARS2.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT785Hu01 Recombinant Leucyl tRNA Synthetase (LARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT785Hu01 Monoclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IP.
PAT785Hu01 Polyclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IF.
Assay Kits CLT785Hu01 CLIA Kit for Leucyl tRNA Synthetase (LARS) CLIA assay for Antigen Detection
ELT785Hu01 ELISA Kit for Leucyl tRNA Synthetase (LARS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT785Mu01 Recombinant Leucyl tRNA Synthetase (LARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT785Mu01 Monoclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IP.
PAT785Mu01 Polyclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IF.
Assay Kits CLT785Mu01 CLIA Kit for Leucyl tRNA Synthetase (LARS) CLIA assay for Antigen Detection
ELT785Mu01 ELISA Kit for Leucyl tRNA Synthetase (LARS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT785Ra01 Recombinant Leucyl tRNA Synthetase (LARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT785Ra01 Monoclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IP.
PAT785Ra01 Polyclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IF.
Assay Kits CLT785Ra01 CLIA Kit for Leucyl tRNA Synthetase (LARS) CLIA assay for Antigen Detection
ELT785Ra01 ELISA Kit for Leucyl tRNA Synthetase (LARS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT785Ca01 Recombinant Leucyl tRNA Synthetase (LARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT785Ca01 Monoclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IP.
PAT785Ca01 Polyclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IF.
Assay Kits CLT785Ca01 CLIA Kit for Leucyl tRNA Synthetase (LARS) CLIA assay for Antigen Detection
ELT785Ca01 ELISA Kit for Leucyl tRNA Synthetase (LARS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT785Po01 Recombinant Leucyl tRNA Synthetase (LARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT785Po01 Monoclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IP.
PAT785Po01 Polyclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IF.
Assay Kits CLT785Po01 CLIA Kit for Leucyl tRNA Synthetase (LARS) CLIA assay for Antigen Detection
ELT785Po01 ELISA Kit for Leucyl tRNA Synthetase (LARS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT785Bo01 Recombinant Leucyl tRNA Synthetase (LARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT785Bo01 Monoclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IP.
PAT785Bo01 Polyclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IF.
Assay Kits CLT785Bo01 CLIA Kit for Leucyl tRNA Synthetase (LARS) CLIA assay for Antigen Detection
ELT785Bo01 ELISA Kit for Leucyl tRNA Synthetase (LARS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT785Rb01 Recombinant Leucyl tRNA Synthetase (LARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT785Rb01 Monoclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IP.
PAT785Rb01 Polyclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IF.
Assay Kits CLT785Rb01 CLIA Kit for Leucyl tRNA Synthetase (LARS) CLIA assay for Antigen Detection
ELT785Rb01 ELISA Kit for Leucyl tRNA Synthetase (LARS) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT785Mo01 Recombinant Leucyl tRNA Synthetase (LARS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT785Mo01 Monoclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IP.
PAT785Mo01 Polyclonal Antibody to Leucyl tRNA Synthetase (LARS) WB; IHC; ICC; IF.
Assay Kits CLT785Mo01 CLIA Kit for Leucyl tRNA Synthetase (LARS) CLIA assay for Antigen Detection
ELT785Mo01 ELISA Kit for Leucyl tRNA Synthetase (LARS) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
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Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles."
J. Mol. Biol. 390:196-207(2009) [PubMed] [Europe PMC] [Abstract]

"Identification of a mutation in LARS as a novel cause of infantile hepatopathy."
Mol. Genet. Metab. 106:351-358(2012) [PubMed] [Europe PMC] [Abstract]