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Histidyl tRNA Synthetase (HARS)

HRS; Jo1; Jo-1; HisRS; Histidine tRNA Ligase 1,Cytoplasmic

Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene.Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl tRNA synthetases.
The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter.TISSUE SPECIFICITY: Brain, heart, liver and kidney.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins T784Hu01 Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
PT784Hu01 Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Histidyl tRNA Synthetase (HARS) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Histidyl tRNA Synthetase (HARS) Bioactivity
Antibodies NONE Monoclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Histidyl tRNA Synthetase (HARS) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Histidyl tRNA Synthetase (HARS) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Histidyl tRNA Synthetase (HARS) CLIA assay for Antigen Detection

Reference

"Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases."
Nucleic Acids Res. 20:1075-1081(1992) [PubMed] [Europe PMC] [Abstract]

"Isolation, structure and expression of mammalian genes for histidyl-tRNA synthetase."
Nucleic Acids Res. 15:3349-3367(1987) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element."
Gene 131:201-208(1993) [PubMed] [Europe PMC] [Abstract]

"A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS."
Biochem. Biophys. Res. Commun. 210:556-566(1995) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"A loss-of-function variant in the human histidyl-tRNA synthetase (HARS) gene is neurotoxic in vivo."
Hum. Mutat. 34:191-199(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structures of the WHEP-TRS domain of human histidyl-tRNA synthetase."
Submitted (NOV-2005) to the PDB data bank

"Genetic mapping and exome sequencing identify variants associated with five novel diseases."
PLoS ONE 7:E28936-E28936(2012) [PubMed] [Europe PMC] [Abstract]