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Follicle Stimulating Hormone Beta (FSHb)

FSH-B; Follitropin Subunit Beta

Follitropin subunit beta is a protein encoded by the FSHB gene.The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein.Defects in FSHB are a cause of isolated follicle- stimulating hormone deficiency (IFSHD). Stimulates development of follicle and spermatogenesis in the reproductive organs.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT766Hu01 Recombinant Follicle Stimulating Hormone Beta (FSHb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT766Hu01 Monoclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IP.
PAT766Hu01 Polyclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IF.
Assay Kits CLT766Hu01 CLIA Kit for Follicle Stimulating Hormone Beta (FSHb) CLIA assay for Antigen Detection
ELT766Hu01 ELISA Kit for Follicle Stimulating Hormone Beta (FSHb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT766Mu01 Recombinant Follicle Stimulating Hormone Beta (FSHb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT766Mu01 Monoclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IP.
PAT766Mu01 Polyclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IF.
Assay Kits CLT766Mu01 CLIA Kit for Follicle Stimulating Hormone Beta (FSHb) CLIA assay for Antigen Detection
ELT766Mu01 ELISA Kit for Follicle Stimulating Hormone Beta (FSHb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT766Ra01 Recombinant Follicle Stimulating Hormone Beta (FSHb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT766Ra01 Monoclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IP.
PAT766Ra01 Polyclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IF.
Assay Kits CLT766Ra01 CLIA Kit for Follicle Stimulating Hormone Beta (FSHb) CLIA assay for Antigen Detection
ELT766Ra01 ELISA Kit for Follicle Stimulating Hormone Beta (FSHb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT766Ca01 Recombinant Follicle Stimulating Hormone Beta (FSHb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT766Ca01 Monoclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IP.
PAT766Ca01 Polyclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IF.
Assay Kits CLT766Ca01 CLIA Kit for Follicle Stimulating Hormone Beta (FSHb) CLIA assay for Antigen Detection
ELT766Ca01 ELISA Kit for Follicle Stimulating Hormone Beta (FSHb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT766Po01 Recombinant Follicle Stimulating Hormone Beta (FSHb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT766Po01 Monoclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IP.
PAT766Po01 Polyclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IF.
Assay Kits CLT766Po01 CLIA Kit for Follicle Stimulating Hormone Beta (FSHb) CLIA assay for Antigen Detection
ELT766Po01 ELISA Kit for Follicle Stimulating Hormone Beta (FSHb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT766Bo01 Recombinant Follicle Stimulating Hormone Beta (FSHb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT766Bo01 Monoclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IP.
PAT766Bo01 Polyclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IF.
Assay Kits CLT766Bo01 CLIA Kit for Follicle Stimulating Hormone Beta (FSHb) CLIA assay for Antigen Detection
ELT766Bo01 ELISA Kit for Follicle Stimulating Hormone Beta (FSHb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT766Rb01 Recombinant Follicle Stimulating Hormone Beta (FSHb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT766Rb01 Monoclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IP.
PAT766Rb01 Polyclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IF.
Assay Kits CLT766Rb01 CLIA Kit for Follicle Stimulating Hormone Beta (FSHb) CLIA assay for Antigen Detection
ELT766Rb01 ELISA Kit for Follicle Stimulating Hormone Beta (FSHb) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT766Mo01 Recombinant Follicle Stimulating Hormone Beta (FSHb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT766Mo01 Monoclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IP.
PAT766Mo01 Polyclonal Antibody to Follicle Stimulating Hormone Beta (FSHb) WB; IHC; ICC; IF.
Assay Kits CLT766Mo01 CLIA Kit for Follicle Stimulating Hormone Beta (FSHb) CLIA assay for Antigen Detection
ELT766Mo01 ELISA Kit for Follicle Stimulating Hormone Beta (FSHb) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11."
DNA 6:205-212(1987) [PubMed] [Europe PMC] [Abstract]

"Expression of biologically active human follitropin in Chinese hamster ovary cells."
J. Biol. Chem. 264:4769-4775(1989) [PubMed] [Europe PMC] [Abstract]

"Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids."
Mol. Endocrinol. 2:806-815(1988) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A reevaluation of the amino acid sequence of human follitropin beta-subunit."
J. Protein Chem. 7:325-339(1988) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands."
J. Biol. Chem. 251:993-1005(1976) [PubMed] [Europe PMC] [Abstract]

"Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb)."
J. Clin. Endocrinol. Metab. 39:203-205(1974) [PubMed] [Europe PMC] [Abstract]

"Studies on the disulfide bonds in human pituitary follicle-stimulating hormone."
Biochim. Biophys. Acta 624:428-435(1980) [PubMed] [Europe PMC] [Abstract]

"Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain."
Biol. Chem. 382:961-968(2001) [PubMed] [Europe PMC] [Abstract]

"Three-dimensional structure of human follicle-stimulating hormone."
Mol. Endocrinol. 15:378-389(2001) [PubMed] [Europe PMC] [Abstract]

"Structure of human follicle-stimulating hormone in complex with its receptor."
Nature 433:269-277(2005) [PubMed] [Europe PMC] [Abstract]

"Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone."
Nat. Genet. 5:83-86(1993) [PubMed] [Europe PMC] [Abstract]

"Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene."
N. Engl. J. Med. 337:607-611(1997) [PubMed] [Europe PMC] [Abstract]

"Isolated deficiency of follicle-stimulating hormone re-revisited."
N. Engl. J. Med. 337:642-642(1997) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)