Fibrinogen Like Protein 1 (FGL1)

FGL-1; HFREP1; HP-041; LFIRE1; Hepassocin; Hepatocyte-derived fibrinogen-related protein 1; Liver fibrinogen-related protein 1

SPN	T760
HGNC	3695
MGI	102795
PubMed	23483972
RGD	620169
UniProt	Q08830
Wiki	FGL1

Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. The deduced 312-amino acid FGL1 protein possesses a hydrophobic leader peptide. FGL1 shares significant sequence homology with FGB and FGG and with other fibrinogen-related proteins. The FGL1 sequence includes 4 cysteine residues that are widely conserved in all fibrinogens and fibrinogen-related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas.

Reference

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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]