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Syntaxin 1A, Brain (STX1A)

STX-1A; HPC-1; STX1; P35-1; Neuron-specific antigen HPC-1

Syntaxin-1A is a protein encoded by the STX1A gene.Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone.
Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis .Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT749Hu01 Recombinant Syntaxin 1A, Brain (STX1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT749Hu01 Monoclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
PAT749Hu01 Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IF.
Assay Kits CLT749Hu01 CLIA Kit for Syntaxin 1A, Brain (STX1A) CLIA assay for Antigen Detection
ELT749Hu01 ELISA Kit for Syntaxin 1A, Brain (STX1A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT749Mu01 Recombinant Syntaxin 1A, Brain (STX1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT749Mu01 Monoclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
PAT749Mu01 Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IF.
Assay Kits CLT749Mu01 CLIA Kit for Syntaxin 1A, Brain (STX1A) CLIA assay for Antigen Detection
ELT749Mu01 ELISA Kit for Syntaxin 1A, Brain (STX1A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT749Ra01 Recombinant Syntaxin 1A, Brain (STX1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT749Ra01 Monoclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
PAT749Ra01 Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IF.
Assay Kits CLT749Ra01 CLIA Kit for Syntaxin 1A, Brain (STX1A) CLIA assay for Antigen Detection
ELT749Ra01 ELISA Kit for Syntaxin 1A, Brain (STX1A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT749Ca01 Recombinant Syntaxin 1A, Brain (STX1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT749Ca01 Monoclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
PAT749Ca01 Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IF.
Assay Kits CLT749Ca01 CLIA Kit for Syntaxin 1A, Brain (STX1A) CLIA assay for Antigen Detection
ELT749Ca01 ELISA Kit for Syntaxin 1A, Brain (STX1A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT749Po01 Recombinant Syntaxin 1A, Brain (STX1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT749Po01 Monoclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
PAT749Po01 Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IF.
Assay Kits CLT749Po01 CLIA Kit for Syntaxin 1A, Brain (STX1A) CLIA assay for Antigen Detection
ELT749Po01 ELISA Kit for Syntaxin 1A, Brain (STX1A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT749Bo01 Recombinant Syntaxin 1A, Brain (STX1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT749Bo01 Monoclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
PAT749Bo01 Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IF.
Assay Kits CLT749Bo01 CLIA Kit for Syntaxin 1A, Brain (STX1A) CLIA assay for Antigen Detection
ELT749Bo01 ELISA Kit for Syntaxin 1A, Brain (STX1A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT749Rb01 Recombinant Syntaxin 1A, Brain (STX1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT749Rb01 Monoclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
PAT749Rb01 Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IF.
Assay Kits CLT749Rb01 CLIA Kit for Syntaxin 1A, Brain (STX1A) CLIA assay for Antigen Detection
ELT749Rb01 ELISA Kit for Syntaxin 1A, Brain (STX1A) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT749Mo01 Recombinant Syntaxin 1A, Brain (STX1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT749Mo01 Monoclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IP.
PAT749Mo01 Polyclonal Antibody to Syntaxin 1A, Brain (STX1A) WB; IHC; ICC; IF.
Assay Kits CLT749Mo01 CLIA Kit for Syntaxin 1A, Brain (STX1A) CLIA assay for Antigen Detection
ELT749Mo01 ELISA Kit for Syntaxin 1A, Brain (STX1A) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis."
Gene 159:293-294(1995) [PubMed] [Europe PMC] [Abstract]

"Hemizygous deletion of the syntaxin 1A gene in individuals with Williams syndrome."
Am. J. Hum. Genet. 61:449-452(1997) [PubMed] [Europe PMC] [Abstract]

"Refinement of the genomic structure of STX1A and mutation analysis in nondeletion Williams syndrome patients."
Am. J. Med. Genet. 109:121-124(2002) [PubMed] [Europe PMC] [Abstract]

"Novel isoform of syntaxin 1 is expressed in mammalian cells."
Biochem. J. 321:151-156(1997) [PubMed] [Europe PMC] [Abstract]

"Mapping of the human HPC-1/syntaxin 1A gene (STX1A) to chromosome 7 band q11.2."
Genomics 42:173-176(1997) [PubMed] [Europe PMC] [Abstract]

"Expression of syntaxin 1C, an alternative splice variant of HPC-1/syntaxin 1A, is enhanced by phorbol-ester stimulation in astroglioma: participation of the PKC signaling pathway."
FEBS Lett. 536:209-214(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression analysis of the human HPC-1/syntaxin 1A, a gene deleted in Williams syndrome."
Genomics 62:525-528(1999) [PubMed] [Europe PMC] [Abstract]

"Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion."
Blood 100:1081-1083(2002) [PubMed] [Europe PMC] [Abstract]

"Ca2+-dependent phosphorylation of syntaxin-1A by the death-associated protein (DAP) kinase regulates its interaction with Munc18."
J. Biol. Chem. 278:26265-26274(2003) [PubMed] [Europe PMC] [Abstract]

"Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons."
Nat. Cell Biol. 6:941-953(2004) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteomic analysis of synaptosomes from human cerebral cortex."
J. Proteome Res. 4:306-315(2005) [PubMed] [Europe PMC] [Abstract]