Immunoglobulin Kappa (Igk)

IGKC; HCAK1; Km; Immunoglobulin Kappa Constant; IgA Kappa

SPN	T746
HGNC	5716
MGI	96495
PubMed	8458340
UniProt	P01834
Wiki	IGKC

Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes a the constant domain of kappa-type light chains for antibodies. It is found on chromosome 2, in humans, within the Immunoglobulin kappa locus, IGK@.The EU sequence has the INV (3) allotypic marker, Ala-45 and Val-83. The ROY sequence has the INV (1,2) allotypic marker, Ala-45 and Leu-83.

Immunoglobulin kappa locus, also known as IGK@, is a region on human chromosome 2 that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins).In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region. These genes undergo V(D)J recombination to generate a diverse repertoire of immunoglobulins.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	PT746Hu01	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	KET746Hu	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	PT746Mu01	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	LT746Mu51	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	LT746Mu41	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	KET746Mu	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Immunoglobulin Kappa (Igk)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Immunoglobulin Kappa (Igk)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Immunoglobulin Kappa (Igk)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Immunoglobulin Kappa (Igk)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Immunoglobulin Kappa (Igk)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Immunoglobulin Kappa (Igk)	CLIA assay for Antigen Detection

Reference

"The covalent structure of a human gamma G-immunoglobulin. VI. Amino acid sequence of the light chain."
Biochemistry 9:3155-3161(1970) [PubMed] [Europe PMC] [Abstract]

"The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds."
Biochemistry 9:3188-3196(1970) [PubMed] [Europe PMC] [Abstract]

"Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production."
Hoppe-Seyler's Z. Physiol. Chem. 353:189-208(1972) [PubMed] [Europe PMC] [Abstract]

"Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments."
Cell 22:197-207(1980) [PubMed] [Europe PMC] [Abstract]

, (In) Franek F., Shugar D. (eds.);Gamma globulins: structure and function, pp.57-74, Academic Press, New York (1969)

"The complete amino acid sequence of Bence Jones protein Cum (kappa-type)."
Hoppe-Seyler's Z. Physiol. Chem. 348:1718-1722(1967) [PubMed] [Europe PMC] [Abstract]

"The amino acid sequence of a kappa type Bence-Jones protein. 3. The complete sequence and the location of the disulfide bridges."
J. Biol. Chem. 244:3550-3560(1969) [PubMed] [Europe PMC] [Abstract]

"Macroglobulin structure: variable sequence of light and heavy chains."
Science 169:56-59(1970) [PubMed] [Europe PMC] [Abstract]

"Extended analysis of AL-amyloid protein from abdominal wall subcutaneous fat biopsy: kappa IV immunoglobulin light chain."
Biochem. Biophys. Res. Commun. 245:713-716(1998) [PubMed] [Europe PMC] [Abstract]

"Molecular defects in a human immunoglobulin kappa chain deficiency."
Science 230:458-461(1985) [PubMed] [Europe PMC] [Abstract]