Neuropilin 2 (NRP2)

NP2; NPN2; VEGF165R2; VEGF165-R2; Vascular endothelial cell growth factor 165 receptor 2

SPN	T742
HGNC	8005
MGI	1100492
PubMed	9331348
RGD	621442
UniProt	O60462
Wiki	NRP2

Neuropilin-2 is a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.Neuropilins work as co-receptors as they have a very small cytoplasmic domain and thus rely upon other molecules to transduce their signals across a cell membrane, normally Plexins.

Reference

"Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III."
Neuron 19:547-559(1997) [PubMed] [Europe PMC] [Abstract]

"Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor."
Cell 92:735-745(1998) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms."
Genomics 70:211-222(2000) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165."
J. Biol. Chem. 275:18040-18045(2000) [PubMed] [Europe PMC] [Abstract]

"Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."
Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]

"Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding."
EMBO J. 26:4902-4912(2007) [PubMed] [Europe PMC] [Abstract]

"de novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP."
Am. J. Hum. Genet. 90:502-510(2012) [PubMed] [Europe PMC] [Abstract]