Opioid Receptor Kappa 1 (OPRk1)

OPR-K; KOR

SPN	T741
HGNC	8154
MGI	97439
PubMed	15608558
RGD	69426
UniProt	P41145
Wiki	OPRK1

The κ-Opioid receptor is a type of opioid receptor which binds the peptide opioid dynorphin as the primary endogenous ligand. κ receptors are widely distributed in the brain (hypothalamus, periaqueductal gray, and claustrum), spinal cord (substantia gelatinosa), and in pain neurons.

Based on receptor binding studies, three variants of the κ-opioid receptor designated κ₁, κ₂, and κ₃ have been characterized. However only one cDNA clone has been identified, hence these receptor subtypes likely arise from interaction of one κ-opioid receptor protein with other membrane associated proteins.κ-Opioid receptor ligands are also known for their characteristic diuretic effects, due to their negative regulation of antidiuretic hormone (ADH).

Reference

"Isolation of a human kappa opioid receptor cDNA from placenta."
Biochem. Biophys. Res. Commun. 202:1431-1437(1994) [PubMed] [Europe PMC] [Abstract]

"Kappa-opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system."
Proc. Natl. Acad. Sci. U.S.A. 92:7006-7010(1995) [PubMed] [Europe PMC] [Abstract]

"Cloning of a human kappa opioid receptor from the brain."
Life Sci. 56:PL201-PL207(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human kappa opiate receptor second extracellular loop elevates dynorphin's affinity for human mu/kappa chimeras."
J. Biol. Chem. 269:25966-25969(1994) [PubMed] [Europe PMC] [Abstract]

"Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate."
J. Biol. Chem. 277:27545-27552(2002) [PubMed] [Europe PMC] [Abstract]

"GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor."
J. Biol. Chem. 281:7983-7993(2006) [PubMed] [Europe PMC] [Abstract]

"N-glycosylation of the human kappa opioid receptor enhances its stability but slows its trafficking along the biosynthesis pathway."
Biochemistry 46:10960-10970(2007) [PubMed] [Europe PMC] [Abstract]

"The role of kappa-opioid receptor activation in mediating antinociception and addiction."
Acta Pharmacol. Sin. 31:1065-1070(2010) [PubMed] [Europe PMC] [Abstract]

"Kinase cascades and ligand-directed signaling at the kappa opioid receptor."
Psychopharmacology 210:137-147(2010) [PubMed] [Europe PMC] [Abstract]

"Structure of the human kappa-opioid receptor in complex with JDTic."
Nature 485:327-332(2012) [PubMed] [Europe PMC] [Abstract]